About   Help   FAQ
Pcyox1 Gene Detail
Summary
  • Symbol
    Pcyox1
  • Name
    prenylcysteine oxidase 1
  • Synonyms
    1200015P13Rik, PCL1, Pcly
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914131
    NCBI Gene: 66881
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:86362988-86374132 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 37.69 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    345 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914131
 protein coding gene Chr6:86362988-86374136 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030974
 protein coding gene Chr6:87663943-87676569 (-)
A/J MGP_AJ_G0030940
 protein coding gene Chr6:84284900-84296605 (-)
AKR/J MGP_AKRJ_G0030871
 protein coding gene Chr6:86722432-86735571 (-)
BALB/cJ MGP_BALBcJ_G0030953
 protein coding gene Chr6:84295780-84307343 (-)
C3H/HeJ MGP_C3HHeJ_G0030757
 protein coding gene Chr6:97721386-97732467 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031410
 protein coding gene Chr6:90046648-90059008 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028594
 protein coding gene Chr6:82461115-82471393 (-)
CAST/EiJ MGP_CASTEiJ_G0030062
 protein coding gene Chr6:86794609-86807112 (-)
CBA/J MGP_CBAJ_G0030637
 protein coding gene Chr6:93588115-93599200 (-)
DBA/2J MGP_DBA2J_G0030793
 protein coding gene Chr6:83602988-83614072 (-)
FVB/NJ MGP_FVBNJ_G0030746
 protein coding gene Chr6:82787478-82798563 (-)
LP/J MGP_LPJ_G0030870
 protein coding gene Chr6:87702050-87713135 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030779
 protein coding gene Chr6:97721802-97732883 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031437
 protein coding gene Chr6:86574130-86585288 (-)
PWK/PhJ MGP_PWKPhJ_G0029777
 protein coding gene Chr6:82545805-82557232 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029605
 protein coding gene Chr6:85408801-85420102 (-)
WSB/EiJ MGP_WSBEiJ_G0030143
 protein coding gene Chr6:87023194-87035016 (-)



Homology
more
  • Human Ortholog
    PCYOX1, prenylcysteine oxidase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PCYOX1, prenylcysteine oxidase 1
  • Synonyms
    PCL1
  • Links
    NCBI Gene ID: 51449
    neXtProt AC: NX_Q9UHG3
    UniProt: Q9UHG3

  • Chr Location
    2p13.3; chr2:70257386-70281185 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    10 phenotype references
Mice homozygous for a knock-out allele are viable, fertile and free of obvious pathology despite a striking accumulation of both farnesylcysteine and geranylgeranylcysteine in brain and liver.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    879
  • Tissues
    131
  • cDNA Data
    182
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 66881 NCBI Gene Model | MGI Sequence Detail 11145 C57BL/6J ±  kb
transcript NM_025823 RefSeq | MGI Sequence Detail 4291 C57BL/6  
polypeptide Q9CQF9 UniProt | EBI | MGI Sequence Detail 505 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 182
    cDNA 182

    Microarray probesets 5
Other
Accession IDs
less
MGI:1353595, MGI:1889828
References
more
  • Summaries
    All 41
    Developmental Gene Expression 3
    Gene Ontology 7
    Phenotypes 10
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:321915 Banfi C, et al., Prenylcysteine Oxidase 1 (PCYOX1), a New Player in Thrombosis. Int J Mol Sci. 2022 Mar 4;23(5)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory