Tmem100 MGI Mouse Gene Detail - MGI:1915138

Symbol

Tmem100
Name

transmembrane protein 100
Synonyms

1810057C19Rik

Feature Type

protein coding gene
IDs

MGI:1915138
NCBI Gene: 67888
Alliance

gene page
Transcription Start Sites

17 TSS

Sequence Map

Chr11:89921174-89927334 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 54.75 cM
Mapping Data

2 experiments

SNPs within 2kb

261 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915138	protein coding gene	Chr11:89921174-89927334 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018936	protein coding gene	Chr11:91829403-91838122 (+)
A/J	MGP_AJ_G0018904	protein coding gene	Chr11:88238767-88244946 (+)
AKR/J	MGP_AKRJ_G0018874	protein coding gene	Chr11:90956801-90962978 (+)
BALB/cJ	MGP_BALBcJ_G0018877	protein coding gene	Chr11:88691547-88697728 (+)
C3H/HeJ	MGP_C3HHeJ_G0018691	protein coding gene	Chr11:90978880-90985032 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019329	protein coding gene	Chr11:94713260-94719404 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016960	protein coding gene	Chr11:85279871-85286022 (+)
CAST/EiJ	MGP_CASTEiJ_G0018246	protein coding gene	Chr11:91720495-91740887 (+)
CBA/J	MGP_CBAJ_G0018662	protein coding gene	Chr11:98662432-98668592 (+)
DBA/2J	MGP_DBA2J_G0018770	protein coding gene	Chr11:87794685-87800848 (+)
FVB/NJ	MGP_FVBNJ_G0018759	protein coding gene	Chr11:87308623-87314799 (+)
LP/J	MGP_LPJ_G0018840	protein coding gene	Chr11:92342756-92348938 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018786	protein coding gene	Chr11:98538905-98546675 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019369	protein coding gene	Chr11:91202623-91208804 (+)
PWK/PhJ	MGP_PWKPhJ_G0018016	protein coding gene	Chr11:88690168-88711240 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017806	protein coding gene	Chr11:90770763-90776920 (+)
WSB/EiJ	MGP_WSBEiJ_G0018295	protein coding gene	Chr11:91069648-91077323 (+)

Human Ortholog

TMEM100, transmembrane protein 100

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TMEM100, transmembrane protein 100
Links

HGNC:25607

NCBI Gene ID: 55273

neXtProt AC: NX_Q9NV29

UniProt: Q9NV29
Chr Location

17q22; chr17:55719627-55732121 (-) GRCh38

MGI Vertebrate Homology

Tmem100 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: TMEM100
Gene Tree

Tmem100

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References

1 with disease annotations

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Phenotype Summary

29 phenotypes from 6 alleles in 5 genetic backgrounds
4 images
26 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Chemically induced (other)

1
Endonuclease-mediated

2
Targeted

13
Genomic Mutations

4 involving Tmem100
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for a null mutations display prenatal lethality. Mice homozygous for one null mutation display defects in arterial differentiation and maturation and complete lethality during organogenesis.

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All GO Annotations

36
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1139
Tissues

227
cDNA Data

18
Literature Summary

21

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tmem100

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All Sequences

38
RefSeq

8
UniProt

1
CCDS

CCDS25239.1

Ensembl

ENSMUSG00000069763 (Evidence)
NCBI Gene

67888

			Length	Strain/Species	Flank
genomic	67888	NCBI Gene Model \| MGI Sequence Detail	6161	C57BL/6J	± kb
transcript	NM_026433	RefSeq \| MGI Sequence Detail	1764	C57BL/6
polypeptide	Q9CQG9	UniProt \| EBI \| MGI Sequence Detail	134	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000030673 transmembrane protein 100

(term hierarchy)
InterPro Domains

IPR032536 Transmembrane protein 100

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All nucleic 20

cDNA 18

Primer pair 2

Microarray probesets 3

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MGI:2144451

Summaries

All 61

Developmental Gene Expression 21

Diseases 1

Gene Ontology 8

Phenotypes 26
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tmem100:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr104091	Chr11:89920481-89920490 (+)	-688 bp
Tssr104092	Chr11:89921121-89921185 (+)	-21 bp
Tssr104093	Chr11:89921490-89921510 (+)	326 bp
Tssr104094	Chr11:89921516-89921534 (+)	351 bp
Tssr104095	Chr11:89921536-89921563 (+)	376 bp
Tssr104096	Chr11:89923821-89923828 (+)	2,651 bp
Tssr104097	Chr11:89923842-89923870 (+)	2,682 bp
Tssr104098	Chr11:89923881-89923898 (+)	2,716 bp
Tssr104099	Chr11:89923912-89923939 (+)	2,752 bp
Tssr104100	Chr11:89924314-89924323 (+)	3,145 bp
Tssr104101	Chr11:89924347-89924402 (+)	3,201 bp
Tssr104102	Chr11:89924408-89924426 (+)	3,243 bp
Tssr104103	Chr11:89924458-89924477 (+)	3,294 bp
Tssr104104	Chr11:89925575-89925587 (+)	4,407 bp
Tssr104105	Chr11:89925604-89925618 (+)	4,437 bp
Tssr104106	Chr11:89926754-89926765 (+)	5,586 bp
Tssr104107	Chr11:89926791-89926802 (+)	5,623 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24