About   Help   FAQ
Rnf2 Gene Detail
Summary
  • Symbol
    Rnf2
  • Name
    ring finger protein 2
  • Synonyms
    dinG, Ring1B
  • Feature Type
    protein coding gene
  • IDs
    MGI:1101759
    NCBI Gene: 19821
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:151345159-151376562 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 64.15 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    868 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1101759
 protein coding gene Chr1:151333755-151376706 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016582
 protein coding gene Chr1:156189786-156234768 (-)
A/J MGP_AJ_G0016564
 protein coding gene Chr1:149881235-149929566 (-)
AKR/J MGP_AKRJ_G0016529
 protein coding gene Chr1:154494310-154538915 (-)
BALB/cJ MGP_BALBcJ_G0016524
 protein coding gene Chr1:150455870-150498230 (-)
C3H/HeJ MGP_C3HHeJ_G0016349
 protein coding gene Chr1:154634958-154680621 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016985
 protein coding gene Chr1:161591801-161638429 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014694
 protein coding gene Chr1:142218910-142257192 (-)
CAST/EiJ MGP_CASTEiJ_G0015928
 protein coding gene Chr1:154066232-154112835 (-)
CBA/J MGP_CBAJ_G0016323
 protein coding gene Chr1:167277887-167320991 (-)
DBA/2J MGP_DBA2J_G0016429
 protein coding gene Chr1:148929006-148971707 (-)
FVB/NJ MGP_FVBNJ_G0016427
 protein coding gene Chr1:147381253-147426677 (-)
LP/J MGP_LPJ_G0016500
 protein coding gene Chr1:157240840-157285983 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016453
 protein coding gene Chr1:174984626-175028122 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017021
 protein coding gene Chr1:154265497-154308569 (-)
PWK/PhJ MGP_PWKPhJ_G0015714
 protein coding gene Chr1:147890599-147934514 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015501
 protein coding gene Chr1:153097473-153141801 (-)
WSB/EiJ MGP_WSBEiJ_G0015991
 protein coding gene Chr1:154361269-154399729 (-)



Homology
more
  • Human Ortholog
    RNF2, ring finger protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RNF2, ring finger protein 2
  • Synonyms
    BAP-1, BAP1, DING, HIPI3, LUSYAM, RING1B, RING2
  • Links
    NCBI Gene ID: 6045
    neXtProt AC: NX_Q99496
    UniProt: Q99496

  • Chr Location
    1q25.3; chr1:185045497-185102603 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human RNF2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 4 alleles in 6 genetic backgrounds
    23 phenotypes from multigenic genotypes
    61 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Embryos homozygous for a null allele show an early growth arrest, failure to progress through gastrulation, impaired epiblast expansion, accumulation of posterior mesoderm and die before E10.5. Mice homozygous for a hypomorphic allele show posterior homeotic transformations of the axial skeleton.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    69
  • GO References
    35
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    807
  • Tissues
    68
  • cDNA Data
    126
  • Literature Summary
    43
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19821 NCBI Gene Model | MGI Sequence Detail 31404 C57BL/6J ±  kb
    transcript NM_001360844 RefSeq | MGI Sequence Detail 3386 C57BL/6  
    polypeptide Q9CQJ4 UniProt | EBI | MGI Sequence Detail 336 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 129
      cDNA 128
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2138212, MGI:2138251, MGI:2138432
    References
    more
    • Summaries
      All 152
      Developmental Gene Expression 43
      Gene Ontology 35
      Phenotypes 61
    • Earliest
      J:43598 Schoorlemmer J, et al., Ring1A is a transcriptional repressor that interacts with the Polycomb-M33 protein and is expressed at rhombomere boundaries in the mouse hindbrain. EMBO J. 1997 Oct 1;16(19):5930-42
    • Latest
      J:341689 Zhang B, et al., KDM2B regulates hippocampal morphogenesis by transcriptionally silencing Wnt signaling in neural progenitors. Nat Commun. 2023 Oct 14;14(1):6489
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory