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Pttg1 Gene Detail
Summary
  • Symbol
    Pttg1
  • Name
    pituitary tumor-transforming gene 1
  • Synonyms
    PTTG, securin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353578
    NCBI Gene: 30939
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
  • Candidate for QTL
    3 QTL
Location &
Maps
more
  • Sequence Map
    Chr11:43311077-43317078 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 25.68 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    405 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1353578
 protein coding gene Chr11:43311077-43317417 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018171
 protein coding gene Chr11:42176812-42186264 (-)
A/J MGP_AJ_G0018143
 protein coding gene Chr11:40573190-40579178 (-)
AKR/J MGP_AKRJ_G0018107
 protein coding gene Chr11:41762931-41768929 (-)
BALB/cJ MGP_BALBcJ_G0018112
 protein coding gene Chr11:40759858-40766015 (-)
C3H/HeJ MGP_C3HHeJ_G0017925
 protein coding gene Chr11:41794215-41801452 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018566
 protein coding gene Chr11:43477841-43484973 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016221
 protein coding gene Chr11:38644582-38649958 (-)
CAST/EiJ MGP_CASTEiJ_G0017489
 protein coding gene Chr11:41847501-41855266 (-)
CBA/J MGP_CBAJ_G0017898
 protein coding gene Chr11:45473038-45482836 (-)
DBA/2J MGP_DBA2J_G0018008
 protein coding gene Chr11:40363017-40369921 (-)
FVB/NJ MGP_FVBNJ_G0018002
 protein coding gene Chr11:40049337-40056097 (-)
LP/J MGP_LPJ_G0018080
 protein coding gene Chr11:42430626-42437422 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018026
 protein coding gene Chr11:47126213-47132093 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018605
 protein coding gene Chr11:41917088-41923944 (-)
PWK/PhJ MGP_PWKPhJ_G0017270
 protein coding gene Chr11:40382598-40388609 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017062
 protein coding gene Chr11:41710671-41716525 (-)
WSB/EiJ MGP_WSBEiJ_G0017538
 protein coding gene Chr11:41557267-41564547 (-)



Homology
more
  • Human Ortholog
    PTTG1, PTTG1 regulator of sister chromatid separation, securin
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PTTG1, PTTG1 regulator of sister chromatid separation, securin
  • Synonyms
    EAP1, ECRAR, HPTTG, PTTG, TUTR1
  • Links
    NCBI Gene ID: 9232
    neXtProt AC: NX_O95997
    UniProt: O95997

  • Chr Location
    5q33.3; chr5:160421855-160428744 (+)  GRCh38
  • Human Ortholog
    PTTG2, pituitary tumor-transforming 2
  • Links
    NCBI Gene ID: 10744
    neXtProt AC: NX_Q9NZH5
    UniProt: Q9NZH5

  • Chr Location
    4p14; chr4:37960398-37961128 (+)  GRCh38
  • Human Ortholog
    PTTG3P, pituitary tumor-transforming 3, pseudogene
  • Synonyms
    PTTG1P3, PTTG3, rcPTTG1
  • Links
    NCBI Gene ID: 26255
    UniProt: Q9NZH4

  • Chr Location
    8q13.1; chr8:66767329-66768034 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    34 phenotypes from 4 alleles in 4 genetic backgrounds
    13 phenotypes from multigenic genotypes
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show testicular and splenic hypoplasia, thymic hyperplasia, thrombocytopenia, aberrant cell cycle progression, chromosome instability, premature centromere division, reduced female fertility, reduced pancreatic betacell mass and sexually-dimorphic diabetes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    773
  • Tissues
    62
  • cDNA Data
    118
  • Literature Summary
    19
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020415 Ensembl Gene Model | MGI Sequence Detail 6002 C57BL/6J ±  kb
    transcript ENSMUST00000020687 Ensembl | MGI Sequence Detail 741 Not Applicable  
    polypeptide ENSMUSP00000020687 Ensembl | MGI Sequence Detail 199 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 119
      cDNA 118
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2144572, MGI:2147417
    References
    more
    • Summaries
      All 100
      Developmental Gene Expression 19
      Gene Ontology 9
      Phenotypes 39
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/22/2024
    MGI 6.24     		The Jackson Laboratory