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Mrfap1 Gene Detail
Summary
  • Symbol
    Mrfap1
  • Name
    Morf4 family associated protein 1
  • Synonyms
    9130413I22Rik, PAM14
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914818
    NCBI Gene: 67568
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:36952211-36954098 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 19.26 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    118 from dbSNP Build 142
  • Strain Annotations
    15
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914818
 protein coding gene Chr5:36952211-36954116 (-)
129S1/SvImJ no annotation
A/J MGP_AJ_G0023802
 protein coding gene Chr17:47352064-47353822 (+)
AKR/J MGP_AKRJ_G0029410
 protein coding gene Chr5:35256459-35257387 (-)
BALB/cJ MGP_BALBcJ_G0029471
 protein coding gene Chr5:34472435-34474929 (-)
C3H/HeJ MGP_C3HHeJ_G0029193
 protein coding gene Chr5:35260414-35262576 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029925
 protein coding gene Chr5:37039742-37043006 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027162
 protein coding gene Chr5:31698904-31700824 (-)
CAST/EiJ MGP_CASTEiJ_G0028602
 protein coding gene Chr5:34398045-34401217 (-)
CBA/J MGP_CBAJ_G0029161
 protein coding gene Chr5:37942448-37947634 (-)
DBA/2J MGP_DBA2J_G0023672
 protein coding gene Chr17:46109614-46111620 (+)
FVB/NJ MGP_FVBNJ_G0023639
 protein coding gene Chr17:45755175-45756330 (+)
LP/J MGP_LPJ_G0023753
 protein coding gene Chr17:49230317-49231709 (+)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0029958
 protein coding gene Chr5:34745086-34749211 (-)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0028158
 protein coding gene Chr5:34217048-34218958 (-)
WSB/EiJ MGP_WSBEiJ_G0028683
 protein coding gene Chr5:34830267-34834446 (-)



Homology
more
  • Human Ortholog
    MRFAP1, Morf4 family associated protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MRFAP1, Morf4 family associated protein 1
  • Synonyms
    PAM14, PGR1
  • Links
    NCBI Gene ID: 93621
    neXtProt AC: NX_Q9Y605
    UniProt: Q9Y605

  • Chr Location
    4p16.1; chr4:6640091-6642729 (+)  GRCh38
  • Human Ortholog
    MRFAP1L1, Morf4 family associated protein 1 like 1
  • Synonyms
    PP784
  • Links
    NCBI Gene ID: 114932
    neXtProt AC: NX_Q96HT8
    UniProt: Q96HT8

  • Chr Location
    4p16.1; chr4:6707701-6709865 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    24 phenotype references
  • All Mutations and Alleles
    10
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    2
  • Gene trapped
    1
  • Radiation induced
    4
  • Spontaneous
    1
  • Targeted
    1
  • Genomic Mutations
    8 involving Mrfap1
  • Incidental Mutations
    CvDC
  • Find Mice (IMSR)
    5 strains or lines available
Homozygous null mice are viable, fertile, develop normally, have normal T cell development and function, and produce MEFs with normal growth rates and times to senescence.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    730
  • Tissues
    6
  • cDNA Data
    14
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 67568 NCBI Gene Model | MGI Sequence Detail 1888 C57BL/6J ±  kb
transcript NM_026242 RefSeq | MGI Sequence Detail 1630 C57BL/6  
polypeptide Q9CQL7 UniProt | EBI | MGI Sequence Detail 125 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 18
    cDNA 17
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2141014
References
more
  • Summaries
    All 46
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 3
    Phenotypes 24
  • Earliest
    J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
  • Latest
    J:125425 Howell GR, et al., Mutation of a ubiquitously expressed mouse transmembrane protein (Tapt1) causes specific skeletal homeotic transformations. Genetics. 2007 Feb;175(2):699-707
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory