Tmem14c MGI Mouse Gene Detail - MGI:1913404

Symbol

Tmem14c
Name

transmembrane protein 14C
Synonyms

1110021D01Rik, HSPC194

Feature Type

protein coding gene
IDs

MGI:1913404
NCBI Gene: 66154
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr13:41169768-41176062 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 20.25 cM
Mapping Data

2 experiments

SNPs within 2kb

255 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913404	protein coding gene	Chr13:41169726-41176062 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020482	protein coding gene	Chr13:39496777-39504739 (+)
A/J	MGP_AJ_G0020436	protein coding gene	Chr13:38173737-38180099 (+)
AKR/J	MGP_AKRJ_G0020414	protein coding gene	Chr13:39216950-39223280 (+)
BALB/cJ	MGP_BALBcJ_G0020432	protein coding gene	Chr13:38363013-38369597 (+)
C3H/HeJ	MGP_C3HHeJ_G0020231	protein coding gene	Chr13:39096500-39105943 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020865	protein coding gene	Chr13:40751622-40757925 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018452	protein coding gene	Chr13:36313924-36320427 (+)
CAST/EiJ	MGP_CASTEiJ_G0019746	protein coding gene	Chr13:38871306-38877754 (+)
CBA/J	MGP_CBAJ_G0020192	protein coding gene	Chr13:42502271-42508500 (+)
DBA/2J	MGP_DBA2J_G0020314	protein coding gene	Chr13:37753079-37759728 (+)
FVB/NJ	MGP_FVBNJ_G0020293	protein coding gene	Chr13:37248511-37255042 (+)
LP/J	MGP_LPJ_G0020389	protein coding gene	Chr13:39738360-39745363 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020322	protein coding gene	Chr13:42469969-42477402 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020908	protein coding gene	Chr13:38865220-38873869 (+)
PWK/PhJ	MGP_PWKPhJ_G0019501	protein coding gene	Chr13:37814732-37821814 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019331	protein coding gene	Chr13:37474229-37480704 (+)
WSB/EiJ	MGP_WSBEiJ_G0019808	protein coding gene	Chr13:39167711-39174165 (+)

Human Ortholog

TMEM14B, transmembrane protein 14B

Vertebrate Orthologs

7

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TMEM14B, transmembrane protein 14B
Links

HGNC:21384

NCBI Gene ID: 81853

neXtProt AC: NX_Q9NUH8

UniProt: Q9NUH8
Chr Location

6p24.2; chr6:10747759-10852753 (+) GRCh38

Human Ortholog

TMEM14C, transmembrane protein 14C
Synonyms

bA421M1.6, C6orf53, HSPC194, MSTP073, NET26
Links

HGNC:20952

NCBI Gene ID: 51522

neXtProt AC: NX_Q9P0S9

UniProt: Q9P0S9
Chr Location

6p24.2; chr6:10722915-10731129 (+) GRCh38

Human Ortholog

TMEM14DP, transmembrane protein 14D, pseudogene
Synonyms

bA524O24.3, TMEM14D
Links

HGNC:15660

NCBI Gene ID: 645203

UniProt: A8MWL7
Chr Location

10q21.3; chr10:68544026-68544940 (-) GRCh38

MGI Vertebrate Homology

Tmem14c stringent orthology
3 human;1 mouse;2 rat;2 zebrafish
HCOP

vertebrate homology predictions: TMEM14B, TMEM14C, TMEM14DP
Gene Tree

Tmem14c

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Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

3
Genomic Mutations

1 involving Tmem14c
Find Mice (IMSR)

4 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gene trapped allele exhibit porphyrin accumulation in fetal liver, erythroid maturation arrest, and embryonic lethality due to severe anemia.

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All GO Annotations

11
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

967
Tissues

88
cDNA Data

173
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tmem14c

ZFIN tmem14ca

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All Sequences

51
RefSeq

6
UniProt

2
CCDS

CCDS26470.1

Ensembl

ENSMUSG00000021361 (Evidence)
NCBI Gene

66154

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021361	Ensembl Gene Model \| MGI Sequence Detail	6295	C57BL/6J	± kb
transcript	ENSMUST00000021790	Ensembl \| MGI Sequence Detail	914	Not Applicable
polypeptide	ENSMUSP00000021790	Ensembl \| MGI Sequence Detail	114	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000031173 transmembrane protein 14C

(term hierarchy)
InterPro Domains

IPR005349 TMEM14 family

IPR044890 TMEM14 superfamily

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All nucleic 175

cDNA 173

Primer pair 1

Other 1

Microarray probesets 3

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MGI:2145355

Summaries

All 35

Developmental Gene Expression 2

Gene Ontology 6

Phenotypes 8
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tmem14c:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr119392	Chr13:41169751-41169785 (+)	0 bp
Tssr119393	Chr13:41169799-41169811 (+)	37 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/22/2024 MGI 6.24