Mmd MGI Mouse Gene Detail - MGI:1914718 - monocyte to macrophage differentiation-associated

Symbol

Mmd
Name

monocyte to macrophage differentiation-associated
Synonyms

1200017E07Rik, 1810073C06Rik, Paqr11

Feature Type

protein coding gene
IDs

MGI:1914718
NCBI Gene: 67468
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr11:90140282-90169415 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 54.89 cM, cytoband C
Mapping Data

3 experiments

SNPs within 2kb

1088 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914718	protein coding gene	Chr11:90078513-90169415 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018937	protein coding gene	Chr11:92001934-92090921 (+)
A/J	MGP_AJ_G0018905	protein coding gene	Chr11:88402447-88493226 (+)
AKR/J	MGP_AKRJ_G0018875	protein coding gene	Chr11:91126043-91218153 (+)
BALB/cJ	MGP_BALBcJ_G0018878	protein coding gene	Chr11:88852172-88941495 (+)
C3H/HeJ	MGP_C3HHeJ_G0018692	protein coding gene	Chr11:91143325-91233074 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019330	protein coding gene	Chr11:94885048-94981724 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016961	protein coding gene	Chr11:85438154-85528449 (+)
CAST/EiJ	MGP_CASTEiJ_G0018247	protein coding gene	Chr11:91878606-91975487 (+)
CBA/J	MGP_CBAJ_G0018663	protein coding gene	Chr11:98827587-98926534 (+)
DBA/2J	MGP_DBA2J_G0018771	protein coding gene	Chr11:87953924-88042681 (+)
FVB/NJ	MGP_FVBNJ_G0018760	protein coding gene	Chr11:87467068-87556628 (+)
LP/J	MGP_LPJ_G0018841	protein coding gene	Chr11:92514341-92617206 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018787	protein coding gene	Chr11:98705648-98801297 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019370	protein coding gene	Chr11:91365821-91461725 (+)
PWK/PhJ	MGP_PWKPhJ_G0018017	protein coding gene	Chr11:88848786-88944035 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017807	protein coding gene	Chr11:90927750-91018602 (+)
WSB/EiJ	MGP_WSBEiJ_G0018296	protein coding gene	Chr11:91239768-91332284 (+)

Human Ortholog

MMD, monocyte to macrophage differentiation associated

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MMD, monocyte to macrophage differentiation associated
Synonyms

MMA, MMD1, PAQR11
Links

HGNC:7153

NCBI Gene ID: 23531

neXtProt AC: NX_Q15546

UniProt: Q15546
Chr Location

17q22; chr17:55392622-55421924 (-) GRCh38

MGI Vertebrate Homology

Mmd stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MMD
Gene Tree

Mmd

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References

1 with disease annotations

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Phenotype Summary

12 phenotypes from 2 alleles in 2 genetic backgrounds
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

2
Targeted

5
Genomic Mutations

4 involving Mmd
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit impaired macrophage differentiation, increased macrophage apoptosis, and decreased susceptibility to induced arthritis.

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All GO Annotations

12
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1052
Tissues

54
cDNA Data

14
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mmd

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All Sequences

47
RefSeq

4
UniProt

1
CCDS

CCDS25240.1

Ensembl

ENSMUSG00000003948 (Evidence)
NCBI Gene

67468

			Length	Strain/Species	Flank
genomic	ENSMUSG00000003948	Ensembl Gene Model \| MGI Sequence Detail	29134	C57BL/6J	± kb
transcript	ENSMUST00000004050	Ensembl \| MGI Sequence Detail	2677	Not Applicable
polypeptide	ENSMUSP00000004050	Ensembl \| MGI Sequence Detail	238	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000010465 monocyte to macrophage differentiation protein

(term hierarchy)

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All nucleic 19

cDNA 17

Primer pair 2

Microarray probesets 7

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MGI:1917116, MGI:2144046

Summaries

All 49

Developmental Gene Expression 6

Diseases 1

Gene Ontology 4

Phenotypes 16
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Mmd:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr104110	Chr11:90140252-90140274 (+)	-19 bp
Tssr104111	Chr11:90140295-90140308 (+)	20 bp
Tssr104112	Chr11:90140313-90140329 (+)	39 bp
Tssr104113	Chr11:90140339-90140358 (+)	67 bp
Tssr104114	Chr11:90140391-90140400 (+)	114 bp
Tssr104115	Chr11:90140406-90140415 (+)	129 bp
Tssr104116	Chr11:90145966-90145985 (+)	5,694 bp
Tssr104117	Chr11:90148187-90148204 (+)	7,914 bp
Tssr104118	Chr11:90148221-90148233 (+)	7,945 bp
Tssr104119	Chr11:90150229-90150261 (+)	9,963 bp
Tssr104120	Chr11:90167755-90167795 (+)	27,493 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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