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Josd2 Gene Detail
Summary
  • Symbol
    Josd2
  • Name
    Josephin domain containing 2
  • Synonyms
    1110007C05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913374
    NCBI Gene: 66124
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:44117404-44121082 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 28.83 cM, cytoband B2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    161 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913374
 protein coding gene Chr7:44117404-44121086 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032163
 protein coding gene Chr7:44638686-44642366 (+)
A/J MGP_AJ_G0032142
 protein coding gene Chr7:43823348-43827030 (+)
AKR/J MGP_AKRJ_G0032078
 protein coding gene Chr7:45025857-45029511 (+)
BALB/cJ MGP_BALBcJ_G0032154
 protein coding gene Chr7:43819757-43823439 (+)
C3H/HeJ MGP_C3HHeJ_G0031870
 protein coding gene Chr7:45517036-45520716 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032646
 protein coding gene Chr7:46894665-46898347 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029660
 protein coding gene Chr7:46409394-46413043 (+)
CAST/EiJ MGP_CASTEiJ_G0031198
 protein coding gene Chr7:36892166-36895810 (+)
CBA/J MGP_CBAJ_G0031834
 protein coding gene Chr7:48417883-48421563 (+)
DBA/2J MGP_DBA2J_G0031992
 protein coding gene Chr7:43497508-43501190 (+)
FVB/NJ MGP_FVBNJ_G0031943
 protein coding gene Chr7:43230995-43234675 (+)
LP/J MGP_LPJ_G0032070
 protein coding gene Chr7:45320968-45324648 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031980
 protein coding gene Chr7:47167586-47171266 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032662
 protein coding gene Chr7:44240088-44243770 (+)
PWK/PhJ MGP_PWKPhJ_G0030921
 protein coding gene Chr7:36842488-36846170 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030758
 protein coding gene Chr7:32250136-32253804 (+)
WSB/EiJ MGP_WSBEiJ_G0031315
 protein coding gene Chr7:44702840-44706522 (+)



Homology
more
  • Human Ortholog
    JOSD2, Josephin domain containing 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    JOSD2, Josephin domain containing 2
  • Synonyms
    SBBI54
  • Links
    NCBI Gene ID: 126119
    neXtProt AC: NX_Q8TAC2
    UniProt: Q8TAC2

  • Chr Location
    19q13.33; chr19:50505998-50511220 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype reference
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    712
  • Tissues
    3
  • cDNA Data
    65
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 66124 NCBI Gene Model | MGI Sequence Detail 3679 C57BL/6J ±  kb
transcript NR_153758 RefSeq | MGI Sequence Detail 1068 C57BL/6  
polypeptide Q9CR30 UniProt | EBI | MGI Sequence Detail 188 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 66
    cDNA 65
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 30
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 1
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:359012 Han J, et al., Deubiquitinase JOSD2 improves calcium handling and attenuates cardiac hypertrophy and dysfunction by stabilizing SERCA2a in cardiomyocytes. Nat Cardiovasc Res. 2023 Aug;2(8):764-777
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory