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Ctrb1 Gene Detail
Summary
  • Symbol
    Ctrb1
  • Name
    chymotrypsinogen B1
  • Synonyms
    2200008D09Rik, Prt-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:88559
    NCBI Gene: 66473
  • Alliance
    gene page
  • Transcription Start Sites
    26 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:112413151-112417642 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 57.98 cM
  • Mapping Data
    15 experiments
Strain
Comparison
more
  • SNPs within 2kb
    260 from dbSNP Build 142
  • Strain Annotations
    17
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88559
 protein coding gene Chr8:112413142-112417642 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034144
 protein coding gene Chr8:114494982-114499468 (-)
A/J MGP_AJ_G0034124
 protein coding gene Chr8:109829965-109834782 (-)
AKR/J MGP_AKRJ_G0034051
 protein coding gene Chr8:113044449-113053599 (-)
BALB/cJ MGP_BALBcJ_G0034118
 protein coding gene Chr8:110006972-110011982 (-)
C3H/HeJ MGP_C3HHeJ_G0033829
 protein coding gene Chr8:113775930-113781796 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034638
 protein coding gene Chr8:118494222-118500145 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031580
 protein coding gene Chr8:102800197-102805196 (-)
CAST/EiJ MGP_CASTEiJ_G0033156
 protein coding gene Chr8:113404790-113409935 (-)
CBA/J MGP_CBAJ_G0033802
 protein coding gene Chr8:122570341-122575767 (-)
DBA/2J MGP_DBA2J_G0033958
 protein coding gene Chr8:109103790-109108443 (-)
FVB/NJ MGP_FVBNJ_G0033901
 protein coding gene Chr8:108081315-108086057 (-)
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0033948
 protein coding gene Chr8:125423538-125428758 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034656
 protein coding gene Chr8:113040679-113045197 (-)
PWK/PhJ MGP_PWKPhJ_G0032858
 protein coding gene Chr8:108702267-108707647 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032698
 protein coding gene Chr8:111688150-111696816 (-)
WSB/EiJ MGP_WSBEiJ_G0033272
 protein coding gene Chr8:113714573-113720788 (-)



Homology
more
  • Human Ortholog
    CTRB1, chymotrypsinogen B1
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CTRB1, chymotrypsinogen B1
  • Synonyms
    CTRB
  • Links
    NCBI Gene ID: 1504
    neXtProt AC: NX_P17538
    UniProt: P17538

  • Chr Location
    16q23.1; chr16:75218988-75226338 (+)  GRCh38
  • Human Ortholog
    CTRB2, chymotrypsinogen B2
  • Links
    NCBI Gene ID: 440387
    neXtProt AC: NX_Q6GPI1
    UniProt: Q6GPI1

  • Chr Location
    16q23.1; chr16:75204103-75207161 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit increased susceptibility to induced pancreatitis with reduced intrapancreatic chymotrypsin activation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    723
  • Tissues
    4
  • cDNA Data
    2152
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031957 Ensembl Gene Model | MGI Sequence Detail 4492 C57BL/6J ±  kb
    transcript ENSMUST00000034435 Ensembl | MGI Sequence Detail 878 Not Applicable  
    polypeptide ENSMUSP00000034435 Ensembl | MGI Sequence Detail 263 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 2154
      cDNA 2153
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-13634, MGD-MRK-2243, MGI:1913723, MGI:2138990
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 8
      Gene Ontology 7
      Phenotypes 7
    • Earliest
      J:5539 Watanabe T, et al., Genetic study of pancreatic proteinase and alpha-amylase in mice (Mus musculus). Biochem Genet. 1974 Nov;12(5):419-28
    • Latest
      J:337474 Cobo I, et al., NFIC regulates ribosomal biology and ER stress in pancreatic acinar cells and restrains PDAC initiation. Nat Commun. 2023 Jun 23;14(1):3761
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/22/2024
    MGI 6.24     		The Jackson Laboratory