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Chchd3 Gene Detail
Summary
  • Symbol
    Chchd3
  • Name
    coiled-coil-helix-coiled-coil-helix domain containing 3
  • Synonyms
    0610041L09Rik, 1700039J09Rik, Micos19
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913325
    NCBI Gene: 66075
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:32769142-33037206 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 13.97 cM, cytoband B1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6464 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913325
 protein coding gene Chr6:32767911-33037206 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030552
 protein coding gene Chr6:30796672-31078058 (-)
A/J MGP_AJ_G0030525
 protein coding gene Chr6:29468745-29752463 (-)
AKR/J MGP_AKRJ_G0030452
 protein coding gene Chr6:30461502-30741953 (-)
BALB/cJ MGP_BALBcJ_G0030535
 protein coding gene Chr6:29600074-29907547 (-)
C3H/HeJ MGP_C3HHeJ_G0030248
 protein coding gene Chr6:30437108-30722579 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030989
 protein coding gene Chr6:31589608-31863150 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028200
 protein coding gene Chr6:27605158-27871184 (-)
CAST/EiJ MGP_CASTEiJ_G0029650
 protein coding gene Chr6:30239300-30510464 (-)
CBA/J MGP_CBAJ_G0030226
 protein coding gene Chr6:32796074-33092171 (-)
DBA/2J MGP_DBA2J_G0030370
 protein coding gene Chr6:29372459-29646660 (-)
FVB/NJ MGP_FVBNJ_G0030324
 protein coding gene Chr6:29161067-29427003 (-)
LP/J MGP_LPJ_G0030457
 protein coding gene Chr6:30932957-31208879 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030360
 protein coding gene Chr6:35159065-35447007 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031019
 protein coding gene Chr6:30343646-30624755 (-)
PWK/PhJ MGP_PWKPhJ_G0029364
 protein coding gene Chr6:28954029-29230495 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029200
 protein coding gene Chr6:30028469-30302685 (-)
WSB/EiJ MGP_WSBEiJ_G0029726
 protein coding gene Chr6:30273315-30546895 (-)



Homology
more
  • Human Ortholog
    CHCHD3, coiled-coil-helix-coiled-coil-helix domain containing 3
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CHCHD3, coiled-coil-helix-coiled-coil-helix domain containing 3
  • Synonyms
    Mic19, MICOS19, MINOS3, PPP1R22
  • Links
    NCBI Gene ID: 54927
    neXtProt AC: NX_Q9NX63
    UniProt: Q9NX63

  • Chr Location
    7q32.3-q33; chr7:132784870-133082090 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a transgenic gene disruption exhibit lethality prior to implantation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    787
  • Tissues
    37
  • cDNA Data
    146
  • Literature Summary
    5
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 66075 NCBI Gene Model | MGI Sequence Detail 268065 C57BL/6J ±  kb
transcript NM_001355667 RefSeq | MGI Sequence Detail 1575 C57BL/6  
polypeptide Q9CRB9 UniProt | EBI | MGI Sequence Detail 227 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000029355 MICOS complex subunit MIC19
    (term hierarchy)
  • InterPro Domains
    IPR052632 MICOS complex subunit Mic19
    IPR007964 MICOS complex subunit MIC19/MIC25
  • GlyGen
    Q9CRB9 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 149
    cDNA 148
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:1920592, MGI:2141712
References
more
  • Summaries
    All 49
    Developmental Gene Expression 5
    Gene Ontology 9
    Phenotypes 10
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:351147 Dong J, et al., Mic19 depletion impairs endoplasmic reticulum-mitochondrial contacts and mitochondrial lipid metabolism and triggers liver disease. Nat Commun. 2024 Jan 2;15(1):168
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory