Ecd MGI Mouse Gene Detail - MGI:1917851 - ecdysoneless cell cycle regulator

Symbol

Ecd
Name

ecdysoneless cell cycle regulator
Synonyms

5730461K03Rik

Feature Type

protein coding gene
IDs

MGI:1917851
NCBI Gene: 70601
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr14:20369927-20398189 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 11.51 cM, cytoband B
Mapping Data

2 experiments

SNPs within 2kb

737 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917851	protein coding gene	Chr14:20369920-20398189 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021031	protein coding gene	Chr14:13064539-13094471 (-)
A/J	MGP_AJ_G0020980	protein coding gene	Chr14:12769998-12798508 (-)
AKR/J	MGP_AKRJ_G0020957	protein coding gene	Chr14:13293734-13321674 (-)
BALB/cJ	MGP_BALBcJ_G0020983	protein coding gene	Chr14:12878013-12907015 (-)
C3H/HeJ	MGP_C3HHeJ_G0020767	protein coding gene	Chr14:13228164-13257139 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021416	protein coding gene	Chr14:13569557-13598512 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018984	protein coding gene	Chr14:13079571-13107936 (-)
CAST/EiJ	MGP_CASTEiJ_G0020291	protein coding gene	Chr14:12995764-13023927 (-)
CBA/J	MGP_CBAJ_G0020733	protein coding gene	Chr14:14247998-14289492 (-)
DBA/2J	MGP_DBA2J_G0020856	protein coding gene	Chr14:12599891-12628604 (-)
FVB/NJ	MGP_FVBNJ_G0020839	protein coding gene	Chr14:12491761-12520429 (-)
LP/J	MGP_LPJ_G0020932	protein coding gene	Chr14:13284762-13315340 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020865	protein coding gene	Chr14:14031369-14064978 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021449	protein coding gene	Chr14:13080223-13109462 (-)
PWK/PhJ	MGP_PWKPhJ_G0020040	protein coding gene	Chr14:12155367-12189375 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019862	protein coding gene	Chr14:12854462-12883008 (-)
WSB/EiJ	MGP_WSBEiJ_G0020347	protein coding gene	Chr14:13061912-13093496 (-)

Human Ortholog

ECD, ecdysoneless cell cycle regulator

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ECD, ecdysoneless cell cycle regulator
Synonyms

GCR2, HSGT1, SGT1
Links

HGNC:17029

NCBI Gene ID: 11319

neXtProt AC: NX_O95905

UniProt: O95905
Chr Location

10q22.2; chr10:73130155-73169055 (-) GRCh38

MGI Vertebrate Homology

Ecd stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ECD
Gene Tree

Ecd

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Endonuclease-mediated

2
Gene trapped

9
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

33 strains or lines available

Mice homozygous for a knock-out allele exhibit lethality (no time point given).

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All GO Annotations

17
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

736
Tissues

21
cDNA Data

127
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ecd

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All Sequences

46
RefSeq

2
UniProt

4
CCDS

CCDS26842.1

Ensembl

ENSMUSG00000021810 (Evidence)
NCBI Gene

70601

			Length	Strain/Species	Flank
genomic	70601	NCBI Gene Model \| MGI Sequence Detail	28263	C57BL/6J	± kb
transcript	NM_027475	RefSeq \| MGI Sequence Detail	3125	C57BL/6
polypeptide	Q9CS74	UniProt \| EBI \| MGI Sequence Detail	641	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000006873 protein ecdysoneless

(term hierarchy)
InterPro Domains

IPR010770 Ecd family
GlyGen

Q9CS74 1 site, 1 O-linked glycan (1 site)

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All nucleic 129

cDNA 129

Microarray probesets 4

Summaries

All 34

Developmental Gene Expression 2

Gene Ontology 6

Phenotypes 7
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:236203 Mir RA, et al., A Novel Interaction of Ecdysoneless (ECD) Protein with R2TP Complex Component RUVBL1 Is Required for the Functional Role of ECD in Cell Cycle Progression. Mol Cell Biol. 2015 Dec 28;36(6):886-99

TSS for Ecd:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr127602	Chr14:20398108-20398169 (-)	50 bp
Tssr127601	Chr14:20398087-20398101 (-)	95 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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