Mtarc1 MGI Mouse Gene Detail - MGI:1913362 - mitochondrial amidoxime reducing component 1

Symbol

Mtarc1
Name

mitochondrial amidoxime reducing component 1
Synonyms

1300013F15Rik, Marc1, Mosc1

Feature Type

protein coding gene
IDs

MGI:1913362
NCBI Gene: 66112
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr1:184518964-184543394 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 89.07 cM, cytoband H4
Mapping Data

2 experiments

SNPs within 2kb

915 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913362	protein coding gene	Chr1:184518964-184543622 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016909	protein coding gene	Chr1:191478698-191504455 (-)
A/J	MGP_AJ_G0016888	protein coding gene	Chr1:183665828-183689489 (-)
AKR/J	MGP_AKRJ_G0016853	protein coding gene	Chr1:189080794-189106039 (-)
BALB/cJ	MGP_BALBcJ_G0016846	protein coding gene	Chr1:184302697-184326519 (-)
C3H/HeJ	MGP_C3HHeJ_G0016670	protein coding gene	Chr1:189919512-189943993 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017309	protein coding gene	Chr1:197597298-197624718 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015016	protein coding gene	Chr1:174659492-174684608 (-)
CAST/EiJ	MGP_CASTEiJ_G0016253	protein coding gene	Chr1:189340626-189368110 (-)
CBA/J	MGP_CBAJ_G0016644	protein coding gene	Chr1:204967549-204991792 (-)
DBA/2J	MGP_DBA2J_G0016750	protein coding gene	Chr1:182427979-182451431 (-)
FVB/NJ	MGP_FVBNJ_G0016746	protein coding gene	Chr1:180525454-180549349 (-)
LP/J	MGP_LPJ_G0016825	protein coding gene	Chr1:192634773-192663303 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016778	protein coding gene	Chr1:211877706-211902087 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017346	protein coding gene	Chr1:188931748-188955873 (-)
PWK/PhJ	MGP_PWKPhJ_G0016040	protein coding gene	Chr1:181622831-181647700 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015816	protein coding gene	Chr1:187896809-187922944 (-)
WSB/EiJ	MGP_WSBEiJ_G0016315	protein coding gene	Chr1:189108138-189133601 (-)

Human Ortholog

MTARC1, mitochondrial amidoxime reducing component 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MTARC1, mitochondrial amidoxime reducing component 1
Synonyms

MARC1, MOSC1
Links

HGNC:26189

NCBI Gene ID: 64757

neXtProt AC: NX_Q5VT66

UniProt: Q5VT66
Chr Location

1q41; chr1:220786352-220819659 (+) GRCh38

MGI Vertebrate Homology

Mtarc1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MTARC1
Gene Tree

Mtarc1

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Phenotype Summary

9 phenotypes from 2 alleles in 2 genetic backgrounds
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

3
Targeted

3
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Male mice homozygous for a null allele show reduced liver triglyceride and phospholipids levels but do not show a hepatoprotective effect when challenged with NAFLD-causing diets.

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All GO Annotations

27
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

37

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mtarc1

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All Sequences

38
RefSeq

5
UniProt

2
CCDS

CCDS69987.1

Ensembl

ENSMUSG00000026621 (Evidence)
NCBI Gene

66112

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026621	Ensembl Gene Model \| MGI Sequence Detail	24431	C57BL/6J	± kb
transcript	ENSMUST00000048462	Ensembl \| MGI Sequence Detail	2039	Not Applicable
polypeptide	ENSMUSP00000035804	Ensembl \| MGI Sequence Detail	340	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000010527 mitochondrial amidoxime-reducing component 1

(term hierarchy)
EC

1.7.-.-
InterPro Domains

IPR005302 Molybdenum cofactor sulfurase, C-terminal

IPR005303 Molybdenum cofactor sulfurase, middle domain

IPR011037 Pyruvate kinase-like, insert domain superfamily
GlyGen

Q9CW42 1 site, 1 O-linked glycan (1 site)

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All nucleic 37

cDNA 37

Microarray probesets 4

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MGI:6368865

Summaries

All 34

Gene Ontology 8

Phenotypes 6
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:346201 Smagris E, et al., Divergent role of Mitochondrial Amidoxime Reducing Component 1 (MARC1) in human and mouse. PLoS Genet. 2024 Mar;20(3):e1011179

TSS for Mtarc1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr15655	Chr1:184543501-184543511 (-)	-112 bp
Tssr15654	Chr1:184543483-184543500 (-)	-98 bp
Tssr15653	Chr1:184543456-184543461 (-)	-65 bp
Tssr15652	Chr1:184543367-184543400 (-)	10 bp
Tssr15651	Chr1:184543353-184543360 (-)	37 bp
Tssr15650	Chr1:184543177-184543188 (-)	211 bp
Tssr15649	Chr1:184525020-184525026 (-)	18,371 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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