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Cd2bp2 Gene Detail
Summary
  • Symbol
    Cd2bp2
  • Name
    CD2 cytoplasmic tail binding protein 2
  • Synonyms
    1500011B02Rik, 2410024K20Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917483
    NCBI Gene: 70233
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:126790832-126795222 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 69.38 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    192 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917483
 protein coding gene Chr7:126790832-126795249 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033023
 protein coding gene Chr7:131522094-131526484 (-)
A/J MGP_AJ_G0033006
 protein coding gene Chr7:128023815-128027746 (-)
AKR/J MGP_AKRJ_G0032938
 protein coding gene Chr7:131273108-131277039 (-)
BALB/cJ MGP_BALBcJ_G0033011
 protein coding gene Chr7:127684974-127689350 (-)
C3H/HeJ MGP_C3HHeJ_G0032721
 protein coding gene Chr7:131207150-131211139 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033517
 protein coding gene Chr7:136632725-136637115 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030489
 protein coding gene Chr7:129236328-129241262 (-)
CAST/EiJ MGP_CASTEiJ_G0032050
 protein coding gene Chr7:123004509-123009657 (-)
CBA/J MGP_CBAJ_G0032694
 protein coding gene Chr7:141225612-141230002 (-)
DBA/2J MGP_DBA2J_G0032846
 protein coding gene Chr7:125994493-125998883 (-)
FVB/NJ MGP_FVBNJ_G0032799
 protein coding gene Chr7:125847905-125852295 (-)
LP/J MGP_LPJ_G0032940
 protein coding gene Chr7:132988998-132993388 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032831
 protein coding gene Chr7:142381482-142385857 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033536
 protein coding gene Chr7:130285323-130289699 (-)
PWK/PhJ MGP_PWKPhJ_G0031757
 protein coding gene Chr7:119003131-119007754 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031603
 protein coding gene Chr7:117124376-117128800 (-)
WSB/EiJ MGP_WSBEiJ_G0032162
 protein coding gene Chr7:131259341-131263535 (-)



Homology
more
  • Human Ortholog
    CD2BP2, CD2 cytoplasmic tail binding protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CD2BP2, CD2 cytoplasmic tail binding protein 2
  • Synonyms
    FWP010, LIN1, PPP1R59, Snu40, U5-52K
  • Links
    NCBI Gene ID: 10421
    neXtProt AC: NX_O95400
    UniProt: O95400

  • Chr Location
    16p11.2; chr16:30350773-30355308 (-)  GRCh38
Human Diseases
less
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 4 genetic backgrounds
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit lethality between E9.5 and E10.5. Mice homozygous for a conditional allele activated in podocytes exhibit proteinuria, weight loss, premature death, glomerulosclerosis, mesangial cell hyperplasia, renal tubule casts, and podocyte foot process effacement.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    743
  • Tissues
    20
  • cDNA Data
    15
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042502 Ensembl Gene Model | MGI Sequence Detail 4391 C57BL/6J ±  kb
    transcript ENSMUST00000166791 Ensembl | MGI Sequence Detail 3284 Not Applicable  
    polypeptide ENSMUSP00000132963 Ensembl | MGI Sequence Detail 342 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 15
      Primer pair 1
      Other 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1916224, MGI:2142191
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 2
      Diseases 2
      Gene Ontology 4
      Phenotypes 40
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:349484 Henis M, et al., The autism susceptibility kinase, TAOK2, phosphorylates eEF2 and modulates translation. Sci Adv. 2024 Apr 12;10(15):eadf7001
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/22/2024
    MGI 6.24     		The Jackson Laboratory