Arhgef25 MGI Mouse Gene Detail - MGI:1277173 - Rho guanine nucleotide exchange factor 25

Symbol

Arhgef25
Name

Rho guanine nucleotide exchange factor 25
Synonyms

2410008H17Rik, D10Ertd610e, GEFT

Feature Type

protein coding gene
IDs

MGI:1277173
NCBI Gene: 52666
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr10:127018394-127025952 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 74.50 cM, cytoband D3
Mapping Data

4 experiments

SNPs within 2kb

206 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1277173	protein coding gene	Chr10:127018390-127025952 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017810	protein coding gene	Chr10:130763910-130771447 (-)
A/J	MGP_AJ_G0017785	protein coding gene	Chr10:125527700-125535233 (-)
AKR/J	MGP_AKRJ_G0017748	protein coding gene	Chr10:129242537-129250074 (-)
BALB/cJ	MGP_BALBcJ_G0017749	protein coding gene	Chr10:125938323-125945859 (-)
C3H/HeJ	MGP_C3HHeJ_G0017573	protein coding gene	Chr10:129383997-129391528 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018204	protein coding gene	Chr10:135200513-135208150 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015884	protein coding gene	Chr10:119535785-119543359 (-)
CAST/EiJ	MGP_CASTEiJ_G0017133	protein coding gene	Chr10:130039717-130047254 (-)
CBA/J	MGP_CBAJ_G0017542	protein coding gene	Chr10:140639922-140647453 (-)
DBA/2J	MGP_DBA2J_G0017648	protein coding gene	Chr10:124620658-124628195 (-)
FVB/NJ	MGP_FVBNJ_G0017643	protein coding gene	Chr10:123560398-123567935 (-)
LP/J	MGP_LPJ_G0017722	protein coding gene	Chr10:131336381-131343917 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017671	protein coding gene	Chr10:143352027-143359564 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018244	protein coding gene	Chr10:129302666-129310203 (-)
PWK/PhJ	MGP_PWKPhJ_G0016918	protein coding gene	Chr10:124816537-124824074 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016710	protein coding gene	Chr10:128338147-128345668 (-)
WSB/EiJ	MGP_WSBEiJ_G0017194	protein coding gene	Chr10:129528940-129536474 (-)

Human Ortholog

ARHGEF25, Rho guanine nucleotide exchange factor 25

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ARHGEF25, Rho guanine nucleotide exchange factor 25
Synonyms

GEFT, p63RhoGEF
Links

HGNC:30275

NCBI Gene ID: 115557

neXtProt AC: NX_Q86VW2

UniProt: Q86VW2
Chr Location

12q13.3; chr12:57610116-57617245 (+) GRCh38

MGI Vertebrate Homology

Arhgef25 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ARHGEF25
Gene Tree

Arhgef25

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
5 phenotype references

All Mutations and Alleles

10
Endonuclease-mediated

1
Gene trapped

8
Targeted

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

37 strains or lines available

Mice homozygous for a conditional allele activated in the second heart field exhibit normal cardiac development and prenatal survival.

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All GO Annotations

10
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

812
Tissues

72
cDNA Data

73
Literature Summary

9

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase arhgef25

ZFIN arhgef25b

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All Sequences

77
RefSeq

15
UniProt

9
CCDS

CCDS24231.1, CCDS48715.1, CCDS88098.1

Ensembl

ENSMUSG00000019467 (Evidence)
NCBI Gene

52666

			Length	Strain/Species	Flank
genomic	ENSMUSG00000019467	Ensembl Gene Model \| MGI Sequence Detail	7559	C57BL/6J	± kb
transcript	ENSMUST00000019611	Ensembl \| MGI Sequence Detail	2218	Not Applicable
polypeptide	ENSMUSP00000019611	Ensembl \| MGI Sequence Detail	618	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000007931 Rho guanine nucleotide exchange factor 25

(term hierarchy)
InterPro Domains

IPR000219 Dbl homology (DH) domain

IPR035899 Dbl homology (DH) domain superfamily

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain

IPR051336 Rho GTPase-activating Guanine Nucleotide Exchange Factors
GlyGen

Q9CWR0 1 site, 1 O-linked glycan (1 site)

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All nucleic 76

cDNA 73

Primer pair 3

Microarray probesets 6

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MGI:1919219

Summaries

All 42

Developmental Gene Expression 9

Gene Ontology 4

Phenotypes 5
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Arhgef25:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr99734	Chr10:127027413-127027425 (-)	-1,467 bp
Tssr99733	Chr10:127025850-127025940 (-)	57 bp
Tssr99732	Chr10:127024697-127024706 (-)	1,250 bp
Tssr99731	Chr10:127024645-127024675 (-)	1,292 bp
Tssr99730	Chr10:127024600-127024632 (-)	1,336 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24