About   Help   FAQ
Rnaseh2a Gene Detail
Summary
  • Symbol
    Rnaseh2a
  • Name
    ribonuclease H2, large subunit
  • Synonyms
    2400006P09Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916974
    NCBI Gene: 69724
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:85683239-85694498 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 41.38 cM, cytoband C3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    421 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916974
 protein coding gene Chr8:85683239-85696396 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033882
 protein coding gene Chr8:85899540-85912524 (-)
A/J MGP_AJ_G0033865
 protein coding gene Chr8:82503179-82517528 (-)
AKR/J MGP_AKRJ_G0033791
 protein coding gene Chr8:84949362-84961286 (-)
BALB/cJ MGP_BALBcJ_G0033858
 protein coding gene Chr8:82636465-82649203 (-)
C3H/HeJ MGP_C3HHeJ_G0033568
 protein coding gene Chr8:85573053-85588112 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034378
 protein coding gene Chr8:89184374-89198474 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031319
 protein coding gene Chr8:76301990-76316254 (-)
CAST/EiJ MGP_CASTEiJ_G0032898
 protein coding gene Chr8:85007099-85019041 (-)
CBA/J MGP_CBAJ_G0033544
 protein coding gene Chr8:92203026-92215950 (-)
DBA/2J MGP_DBA2J_G0033697
 protein coding gene Chr8:82143952-82156959 (-)
FVB/NJ MGP_FVBNJ_G0033645
 protein coding gene Chr8:81096748-81111608 (-)
LP/J MGP_LPJ_G0033789
 protein coding gene Chr8:86002035-86013785 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033687
 protein coding gene Chr8:94768117-94790899 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034395
 protein coding gene Chr8:84937598-84951164 (-)
PWK/PhJ MGP_PWKPhJ_G0032602
 protein coding gene Chr8:81391804-81404050 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032438
 protein coding gene Chr8:83750108-83762612 (-)
WSB/EiJ MGP_WSBEiJ_G0033011
 protein coding gene Chr8:85370135-85385114 (-)



Homology
more
  • Human Ortholog
    RNASEH2A, ribonuclease H2 subunit A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RNASEH2A, ribonuclease H2 subunit A
  • Synonyms
    AGS4, JUNB, RNASEHI, RNHIA, RNHL
  • Links
    NCBI Gene ID: 10535
    neXtProt AC: NX_O75792
    UniProt: O75792

  • Chr Location
    19p13.13; chr19:12806584-12813640 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human RNASEH2A associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotypes from multigenic genotypes
    47 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased embryo and fetal size and complete perinatal lethality, with innate immune activation of IFN-stimulated genes and decreased susceptibility to viral infection observed in mouse embryonic fibroblasts.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    737
  • Tissues
    23
  • cDNA Data
    87
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 69724 NCBI Gene Model | MGI Sequence Detail 11260 C57BL/6J ±  kb
    transcript NM_027187 RefSeq | MGI Sequence Detail 2117 C57BL/6  
    polypeptide Q9CWY8 UniProt | EBI | MGI Sequence Detail 301 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 88
      cDNA 87
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 74
      Developmental Gene Expression 2
      Gene Ontology 8
      Phenotypes 47
    • Earliest
      J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory