Lrrc17 MGI Mouse Gene Detail - MGI:1921761 - leucine rich repeat containing 17

Symbol

Lrrc17
Name

leucine rich repeat containing 17
Synonyms

37kDa, 4833425M04Rik, 6130400C22Rik

Feature Type

protein coding gene
IDs

MGI:1921761
NCBI Gene: 74511
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr5:21748557-21780902 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 9.89 cM
Mapping Data

2 experiments

SNPs within 2kb

1123 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921761	protein coding gene	Chr5:21748525-21780909 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029319	protein coding gene	Chr5:19097803-19129698 (+)
A/J	MGP_AJ_G0029284	protein coding gene	Chr5:18480950-18514235 (+)
AKR/J	MGP_AKRJ_G0029235	protein coding gene	Chr5:19183089-19215371 (+)
BALB/cJ	MGP_BALBcJ_G0029296	protein coding gene	Chr5:18918561-18952334 (+)
C3H/HeJ	MGP_C3HHeJ_G0029015	protein coding gene	Chr5:19253451-19287812 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029749	protein coding gene	Chr5:20504504-20538354 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026988	protein coding gene	Chr5:16538501-16570599 (+)
CAST/EiJ	MGP_CASTEiJ_G0028427	protein coding gene	Chr5:18576537-18614105 (+)
CBA/J	MGP_CBAJ_G0028982	protein coding gene	Chr5:20714255-20751595 (+)
DBA/2J	MGP_DBA2J_G0029134	protein coding gene	Chr5:18765109-18797725 (+)
FVB/NJ	MGP_FVBNJ_G0029092	protein coding gene	Chr5:18171525-18205493 (+)
LP/J	MGP_LPJ_G0029218	protein coding gene	Chr5:19512285-19544216 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029120	protein coding gene	Chr5:22013765-22046065 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029782	protein coding gene	Chr5:18845119-18878890 (+)
PWK/PhJ	MGP_PWKPhJ_G0028150	protein coding gene	Chr5:17813331-17845574 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027983	protein coding gene	Chr5:18205178-18241850 (+)
WSB/EiJ	MGP_WSBEiJ_G0028507	protein coding gene	Chr5:18904374-18937486 (+)

Human Ortholog

LRRC17, leucine rich repeat containing 17

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LRRC17, leucine rich repeat containing 17
Synonyms

P37NB
Links

HGNC:16895

NCBI Gene ID: 10234

neXtProt AC: NX_Q8N6Y2

UniProt: Q8N6Y2
Chr Location

7q22.1; chr7:102913000-102945111 (+) GRCh38

MGI Vertebrate Homology

Lrrc17 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LRRC17
Gene Tree

Lrrc17

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References

1 with disease annotations

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Phenotype Summary

12 phenotypes from 1 allele in 1 genetic background
8 phenotypes from multigenic genotypes
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

2
Endonuclease-mediated

2
Radiation induced

1
Spontaneous

1
Targeted

5
Genomic Mutations

4 involving Lrrc17
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a targeted allele exhibit normal phenotype.

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All GO Annotations

7
GO References

2

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

737
Tissues

17
cDNA Data

49
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas

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All Sequences

32
RefSeq

2
UniProt

1
CCDS

CCDS51428.1

Ensembl

ENSMUSG00000039883 (Evidence)
NCBI Gene

74511

			Length	Strain/Species	Flank
genomic	ENSMUSG00000039883	Ensembl Gene Model \| MGI Sequence Detail	32346	C57BL/6J	± kb
transcript	ENSMUST00000035651	Ensembl \| MGI Sequence Detail	2154	Not Applicable
polypeptide	ENSMUSP00000038569	Ensembl \| MGI Sequence Detail	443	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000032087 leucine-rich repeat-containing protein 17

(term hierarchy)
InterPro Domains

IPR000483 Cysteine-rich flanking region, C-terminal

IPR001611 Leucine-rich repeat

IPR050541 Leucine-rich repeat and transmembrane domain-containing protein

IPR032675 Leucine-rich repeat domain superfamily

IPR003591 Leucine-rich repeat, typical subtype

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All nucleic 54

Genomic 1

cDNA 50

Primer pair 2

Other 1

Microarray probesets 2

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MGI:1921859

Summaries

All 40

Developmental Gene Expression 4

Diseases 1

Gene Ontology 2

Phenotypes 15
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Lrrc17:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr45335	Chr5:21748483-21748494 (+)	-68 bp
Tssr45336	Chr5:21748502-21748519 (+)	-46 bp
Tssr45337	Chr5:21748523-21748588 (+)	-1 bp
Tssr45338	Chr5:21748591-21748610 (+)	44 bp
Tssr45339	Chr5:21748615-21748636 (+)	69 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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