Kynu MGI Mouse Gene Detail - MGI:1918039

Symbol

Kynu
Name

kynureninase
Synonyms

4432411A05Rik, L-kynurenine hydrolase

Feature Type

protein coding gene
IDs

MGI:1918039
NCBI Gene: 70789
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr2:43445341-43572734 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 25.64 cM, cytoband C1
Mapping Data

2 experiments

SNPs within 2kb

3743 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918039	protein coding gene	Chr2:43445270-43572734 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025715	protein coding gene	Chr2:42539709-42674927 (+)
A/J	MGP_AJ_G0025691	protein coding gene	Chr2:40828953-40957341 (+)
AKR/J	MGP_AKRJ_G0025661	protein coding gene	Chr2:42088788-42222120 (+)
BALB/cJ	MGP_BALBcJ_G0025686	protein coding gene	Chr2:40891498-41016664 (+)
C3H/HeJ	MGP_C3HHeJ_G0025447	protein coding gene	Chr2:42030491-42166654 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026132	protein coding gene	Chr2:43820550-43965003 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023538	protein coding gene	Chr2:39165345-39293479 (+)
CAST/EiJ	MGP_CASTEiJ_G0024912	protein coding gene	Chr2:42029244-42176525 (+)
CBA/J	MGP_CBAJ_G0025427	protein coding gene	Chr2:45525639-45678506 (+)
DBA/2J	MGP_DBA2J_G0025558	protein coding gene	Chr2:40499807-40626570 (+)
FVB/NJ	MGP_FVBNJ_G0025520	protein coding gene	Chr2:40331133-40455730 (+)
LP/J	MGP_LPJ_G0025646	protein coding gene	Chr2:42366127-42500991 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025551	protein coding gene	Chr2:45794687-45941700 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026190	protein coding gene	Chr2:41997908-42132407 (+)
PWK/PhJ	MGP_PWKPhJ_G0024653	protein coding gene	Chr2:40422509-40549696 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024458	protein coding gene	Chr2:42082597-42221900 (+)
WSB/EiJ	MGP_WSBEiJ_G0024979	protein coding gene	Chr2:42163516-42299100 (+)

Human Ortholog

KYNU, kynureninase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KYNU, kynureninase
Synonyms

KYNUU, VCRL2
Links

HGNC:6469

NCBI Gene ID: 8942

neXtProt AC: NX_Q16719

UniProt: Q16719
Chr Location

2q22.2; chr2:142877657-143055833 (+) GRCh38

MGI Vertebrate Homology

Kynu stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: KYNU
Protein SuperFamily

KYNU
Gene Tree

Kynu

Diseases

1 with human KYNU associations

				Human Disease	Mouse Models
				hydroxykynureninuria IDs hydroxykynureninuria DOID:0112257 MESH:C536081 OMIM:236800 ORDO:79155

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

14 phenotypes from 2 alleles in 2 genetic backgrounds
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

4
Targeted

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

33 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

34
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

22

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase kynu

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All Sequences

58
RefSeq

12
UniProt

6
CCDS

CCDS16018.1, CCDS79791.1, CCDS79792.1

Ensembl

ENSMUSG00000026866 (Evidence)
NCBI Gene

70789

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026866	Ensembl Gene Model \| MGI Sequence Detail	127394	C57BL/6J	± kb
transcript	ENSMUST00000240759	Ensembl \| MGI Sequence Detail	2008	Not Applicable
polypeptide	ENSMUSP00000159520	Ensembl \| MGI Sequence Detail	464	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000009598 kynureninase

(term hierarchy)
EC

3.7.1.3
InterPro Domains

IPR000192 Aminotransferase class V domain

IPR010111 Kynureninase

IPR015424 Pyridoxal phosphate-dependent transferase

IPR015421 Pyridoxal phosphate-dependent transferase, major domain

IPR015422 Pyridoxal phosphate-dependent transferase, small domain
GlyGen

Q9CXF0 1 site, 1 O-linked glycan (1 site)

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All nucleic 22

cDNA 22

Microarray probesets 4

Summaries

All 38

Gene Ontology 11

Phenotypes 8
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Kynu:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr17589	Chr2:43445333-43445350 (+)	1 bp
Tssr17590	Chr2:43445357-43445367 (+)	21 bp
Tssr17591	Chr2:43445374-43445379 (+)	36 bp
Tssr17592	Chr2:43515172-43515182 (+)	69,836 bp
Tssr17593	Chr2:43525296-43525302 (+)	79,958 bp
Tssr17594	Chr2:43549664-43549666 (+)	104,324 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24