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Zcchc8 Gene Detail
Summary
  • Symbol
    Zcchc8
  • Name
    zinc finger, CCHC domain containing 8
  • Synonyms
    5730565F05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917900
    NCBI Gene: 70650
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:123836365-123859107 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 63.14 cM, cytoband F
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    710 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917900
 protein coding gene Chr5:123836357-123859163 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030077
 protein coding gene Chr5:127452429-127477738 (-)
A/J MGP_AJ_G0030042
 protein coding gene Chr5:122155181-122178150 (-)
AKR/J MGP_AKRJ_G0029978
 protein coding gene Chr5:126095574-126118399 (-)
BALB/cJ MGP_BALBcJ_G0030053
 protein coding gene Chr5:123484505-123512133 (-)
C3H/HeJ MGP_C3HHeJ_G0029770
 protein coding gene Chr5:126704538-126727488 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030506
 protein coding gene Chr5:132396621-132422011 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027732
 protein coding gene Chr5:116701458-116726127 (-)
CAST/EiJ MGP_CASTEiJ_G0029179
 protein coding gene Chr5:125807418-125832556 (-)
CBA/J MGP_CBAJ_G0029740
 protein coding gene Chr5:137585871-137610310 (-)
DBA/2J MGP_DBA2J_G0029890
 protein coding gene Chr5:122170879-122194385 (-)
FVB/NJ MGP_FVBNJ_G0029846
 protein coding gene Chr5:121212558-121235171 (-)
LP/J MGP_LPJ_G0029979
 protein coding gene Chr5:127989666-128020076 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029877
 protein coding gene Chr5:141204474-141227962 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030547
 protein coding gene Chr5:125695830-125720238 (-)
PWK/PhJ MGP_PWKPhJ_G0028893
 protein coding gene Chr5:120989250-121012786 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028730
 protein coding gene Chr5:123367280-123390057 (-)
WSB/EiJ MGP_WSBEiJ_G0029254
 protein coding gene Chr5:126387638-126410185 (-)



Homology
more
  • Human Ortholog
    ZCCHC8, zinc finger CCHC-type containing 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZCCHC8, zinc finger CCHC-type containing 8
  • Synonyms
    PFBMFT5
  • Links
    NCBI Gene ID: 55596
    neXtProt AC: NX_Q6NZY4
    UniProt: Q6NZY4

  • Chr Location
    12q24.31; chr12:122471600-122500932 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show partial lethality by E17.5 and lower survival rate in the first 3 months, small body size, infertility, small testes and ovaries, loss of sperm, fewer mature ovarian follicles, and oocyte maturation defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    721
  • Tissues
    12
  • cDNA Data
    89
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 70650 NCBI Gene Model | MGI Sequence Detail 22743 C57BL/6J ±  kb
    transcript NM_027494 RefSeq | MGI Sequence Detail 4286 C57BL/6  
    polypeptide Q9CYA6 UniProt | EBI | MGI Sequence Detail 709 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000017608 zinc finger CCHC domain-containing protein 8
      (term hierarchy)
    • InterPro Domains
      IPR052115 Nuclear exosome targeting complex subunit ZCCHC8
      IPR006568 PSP, proline-rich
      IPR001878 Zinc finger, CCHC-type
    • GlyGen
      Q9CYA6 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 92
      cDNA 90
      Primer pair 1
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 4
      Gene Ontology 6
      Phenotypes 12
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:297024 Wu Y, et al., Nuclear Exosome Targeting Complex Core Factor Zcchc8 Regulates the Degradation of LINE1 RNA in Early Embryos and Embryonic Stem Cells. Cell Rep. 2019 Nov 19;29(8):2461-2472.e6
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory