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Dcp2 Gene Detail
Summary
  • Symbol
    Dcp2
  • Name
    decapping mRNA 2
  • Synonyms
    2410015D23Rik, 5730537H01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917890
    NCBI Gene: 70640
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:44513569-44558036 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 23.74 cM, cytoband B3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1532 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917890
 protein coding gene Chr18:44513567-44558036 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024400
 protein coding gene Chr18:43118834-43165996 (+)
A/J MGP_AJ_G0024367
 protein coding gene Chr18:41576348-41621466 (+)
AKR/J MGP_AKRJ_G0024336
 protein coding gene Chr18:42750869-42795530 (+)
BALB/cJ MGP_BALBcJ_G0024367
 protein coding gene Chr18:41671060-41715056 (+)
C3H/HeJ MGP_C3HHeJ_G0024134
 protein coding gene Chr18:42778358-42822089 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024811
 protein coding gene Chr18:44613484-44660510 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022246
 protein coding gene Chr18:41366346-41412921 (+)
CAST/EiJ MGP_CASTEiJ_G0023608
 protein coding gene Chr18:42774945-42820391 (+)
CBA/J MGP_CBAJ_G0024103
 protein coding gene Chr18:45834467-45881140 (+)
DBA/2J MGP_DBA2J_G0024233
 protein coding gene Chr18:41198101-41241873 (+)
FVB/NJ MGP_FVBNJ_G0024199
 protein coding gene Chr18:40792192-40837181 (+)
LP/J MGP_LPJ_G0024317
 protein coding gene Chr18:43144950-43195884 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024230
 protein coding gene Chr18:47202085-47252380 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024858
 protein coding gene Chr18:42623212-42668216 (+)
PWK/PhJ MGP_PWKPhJ_G0023352
 protein coding gene Chr18:41384206-41429687 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023158
 protein coding gene Chr18:42846964-42891800 (+)
WSB/EiJ MGP_WSBEiJ_G0023671
 protein coding gene Chr18:42545999-42589816 (+)



Homology
more
  • Human Ortholog
    DCP2, decapping mRNA 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DCP2, decapping mRNA 2
  • Synonyms
    NUDT20
  • Links
    NCBI Gene ID: 167227
    neXtProt AC: NX_Q8IU60
    UniProt: Q8IU60

  • Chr Location
    5q22.2; chr5:112976702-113022195 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 5 alleles in 5 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele are viable and fertile. Mice homozygous for a null allele exhibit male infertility with reduced sperm numbers and motility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    772
  • Tissues
    29
  • cDNA Data
    94
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024472 Ensembl Gene Model | MGI Sequence Detail 44468 C57BL/6J ±  kb
    transcript ENSMUST00000025350 Ensembl | MGI Sequence Detail 8616 Not Applicable  
    polypeptide ENSMUSP00000025350 Ensembl | MGI Sequence Detail 422 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 96
      cDNA 94
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1913674, MGI:3035096
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 6
      Gene Ontology 8
      Phenotypes 16
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:346062 Perez RC, et al., TOB1 and TOB2 mark distinct RNA processing granules in differentiating lens fiber cells. J Mol Histol. 2024 Feb;55(1):121-138
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory