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Crtap Gene Detail
Summary
  • Symbol
    Crtap
  • Name
    cartilage associated protein
  • Synonyms
    5730529N23Rik, CASP, Leprel3, P3h5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891221
    NCBI Gene: 56693
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:114204204-114219743 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 64.39 cM, cytoband F3-F4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    632 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891221
 protein coding gene Chr9:114204202-114219743 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035385
 protein coding gene Chr9:116786592-116802201 (-)
A/J MGP_AJ_G0035365
 protein coding gene Chr9:112204416-112546099 (-)
AKR/J MGP_AKRJ_G0035298
 protein coding gene Chr9:115385855-115402762 (-)
BALB/cJ MGP_BALBcJ_G0035361
 protein coding gene Chr9:112307958-112343934 (-)
C3H/HeJ MGP_C3HHeJ_G0035069
 protein coding gene Chr9:115887740-115914364 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035884
 protein coding gene Chr9:119989165-120009683 (-)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0034374
 protein coding gene Chr9:115485536-115753911 (-)
CBA/J MGP_CBAJ_G0035036
 protein coding gene Chr9:124477673-124493319 (-)
DBA/2J MGP_DBA2J_G0035195
 protein coding gene Chr9:112005839-112021750 (-)
FVB/NJ MGP_FVBNJ_G0035142
 protein coding gene Chr9:110797713-110835840 (-)
LP/J MGP_LPJ_G0035274
 protein coding gene Chr9:117132203-117160780 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035183
 protein coding gene Chr9:125705237-125744092 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035903
 protein coding gene Chr9:115751211-115768659 (-)
PWK/PhJ MGP_PWKPhJ_G0034079
 protein coding gene Chr9:111930814-112321519 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033914
 protein coding gene Chr9:115672233-115816279 (-)
WSB/EiJ MGP_WSBEiJ_G0034494
 protein coding gene Chr9:115636390-115651828 (-)



Homology
more
  • Human Ortholog
    CRTAP, cartilage associated protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CRTAP, cartilage associated protein
  • Synonyms
    CASP, LEPREL3, OI7, P3H5
  • Links
    NCBI Gene ID: 10491
    neXtProt AC: NX_O75718
    UniProt: O75718

  • Chr Location
    3p22.3; chr3:33114014-33147773 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Crtap mouse models; 1 with human CRTAP associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes develop kyphoscoliosis and osteoporosis as a result of defects in bone formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    735
  • Tissues
    29
  • cDNA Data
    70
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56693 NCBI Gene Model | MGI Sequence Detail 15540 C57BL/6J ±  kb
    transcript NM_019922 RefSeq | MGI Sequence Detail 1672 C57BL/6  
    polypeptide Q9CYD3 UniProt | EBI | MGI Sequence Detail 400 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000005900 cartilage-associated protein
      (term hierarchy)
    • InterPro Domains
      IPR052284 Collagen-modifying leprecan protein
      IPR011990 Tetratricopeptide-like helical domain superfamily
    • GlyGen
      Q9CYD3 2 sites, 3 N-linked glycans (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 72
      Genomic 1
      cDNA 71

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1915200
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 6
      Phenotypes 15
    • Earliest
      J:56594 Morello R, et al., cDNA cloning, characterization and chromosome mapping of Crtap encoding the mouse cartilage associated protein. Matrix Biol. 1999 Jun;18(3):319-24
    • Latest
      J:308056 Grol MW, et al., Tendon and motor phenotypes in the Crtap(-/-) mouse model of recessive osteogenesis imperfecta. Elife. 2021 May 26;10:e63488
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory