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Wars2 Gene Detail
Summary
  • Symbol
    Wars2
  • Name
    tryptophanyl tRNA synthetase 2 (mitochondrial)
  • Synonyms
    9430020O07Rik, TrpRS
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917810
    NCBI Gene: 70560
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:99047423-99128546 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 43.03 cM, cytoband F3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2159 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917810
 protein coding gene Chr3:99047423-99146502 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027662
 protein coding gene Chr3:100204555-100309448 (+)
A/J MGP_AJ_G0027621
 protein coding gene Chr3:97009142-97109031 (+)
AKR/J MGP_AKRJ_G0027587
 protein coding gene Chr3:99349082-99456270 (+)
BALB/cJ MGP_BALBcJ_G0027634
 protein coding gene Chr3:96818834-96917670 (+)
C3H/HeJ MGP_C3HHeJ_G0027363
 protein coding gene Chr3:99697070-99798549 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028077
 protein coding gene Chr3:103897740-103997695 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025418
 protein coding gene Chr3:93302249-93402606 (+)
CAST/EiJ MGP_CASTEiJ_G0026819
 protein coding gene Chr3:98827093-98930487 (+)
CBA/J MGP_CBAJ_G0027338
 protein coding gene Chr3:107592093-107699081 (+)
DBA/2J MGP_DBA2J_G0027481
 protein coding gene Chr3:96294479-96393035 (+)
FVB/NJ MGP_FVBNJ_G0027449
 protein coding gene Chr3:94238084-94336700 (+)
LP/J MGP_LPJ_G0027588
 protein coding gene Chr3:101574363-101682366 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027479
 protein coding gene Chr3:113701085-113810916 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028132
 protein coding gene Chr3:98910661-99011290 (+)
PWK/PhJ MGP_PWKPhJ_G0026546
 protein coding gene Chr3:96062679-96162287 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026368
 protein coding gene Chr3:96997245-97112509 (+)
WSB/EiJ MGP_WSBEiJ_G0026899
 protein coding gene Chr3:99457997-99564930 (+)



Homology
more
  • Human Ortholog
    WARS2, tryptophanyl tRNA synthetase 2, mitochondrial
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WARS2, tryptophanyl tRNA synthetase 2, mitochondrial
  • Synonyms
    mtTrpRS, NEMMLAS, PKDYS3, TrpRS
  • Links
    NCBI Gene ID: 10352
    neXtProt AC: NX_Q9UGM6
    UniProt: Q9UGM6

  • Chr Location
    1p12; chr1:119031216-119140672 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced mutation exhibit decreased body fat mass, cardiomyopathy, and progressive hearing loss.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    810
  • Tissues
    101
  • cDNA Data
    34
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 70560 NCBI Gene Model | MGI Sequence Detail 81124 C57BL/6J ±  kb
    transcript NR_185000 RefSeq | MGI Sequence Detail 5146 C57BL/6  
    polypeptide Q9CYK1 UniProt | EBI | MGI Sequence Detail 360 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 35
      cDNA 35

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1924510, MGI:2139688
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 10
      Phenotypes 13
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory