Qrsl1 MGI Mouse Gene Detail - MGI:1923813 - glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1

Symbol

Qrsl1
Name

glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1
Synonyms

2700038P16Rik, GatA

Feature Type

protein coding gene
IDs

MGI:1923813
NCBI Gene: 76563
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr10:43750184-43777741 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 23.11 cM, cytoband B2
Mapping Data

3 experiments

SNPs within 2kb

733 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1923813	protein coding gene	Chr10:43750184-43777742 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017197	protein coding gene	Chr10:42662675-42689952 (-)
A/J	MGP_AJ_G0017175	protein coding gene	Chr10:41474897-41502567 (-)
AKR/J	MGP_AKRJ_G0017135	protein coding gene	Chr10:42104128-42132246 (-)
BALB/cJ	MGP_BALBcJ_G0017136	protein coding gene	Chr10:41517191-41541733 (-)
C3H/HeJ	MGP_C3HHeJ_G0016957	protein coding gene	Chr10:42458407-42483753 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017596	protein coding gene	Chr10:43990722-44022355 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015291	protein coding gene	Chr10:39407856-39434062 (-)
CAST/EiJ	MGP_CASTEiJ_G0016536	protein coding gene	Chr10:42690155-42718174 (-)
CBA/J	MGP_CBAJ_G0016931	protein coding gene	Chr10:45983897-46013122 (-)
DBA/2J	MGP_DBA2J_G0017037	protein coding gene	Chr10:40929462-40954516 (-)
FVB/NJ	MGP_FVBNJ_G0017032	protein coding gene	Chr10:40420329-40447186 (-)
LP/J	MGP_LPJ_G0017113	protein coding gene	Chr10:42702013-42730602 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017061	protein coding gene	Chr10:46663945-46693867 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017632	protein coding gene	Chr10:42128944-42154361 (-)
PWK/PhJ	MGP_PWKPhJ_G0016315	protein coding gene	Chr10:40833396-40858644 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016100	protein coding gene	Chr10:41963075-41988056 (-)
WSB/EiJ	MGP_WSBEiJ_G0016599	protein coding gene	Chr10:42392799-42421701 (-)

Human Ortholog

QRSL1, glutaminyl-tRNA amidotransferase subunit QRSL1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

QRSL1, glutaminyl-tRNA amidotransferase subunit QRSL1
Synonyms

COXPD40, GatA
Links

HGNC:21020

NCBI Gene ID: 55278

neXtProt AC: NX_Q9H0R6

UniProt: Q9H0R6
Chr Location

6q21; chr6:106629578-106668417 (+) GRCh38

MGI Vertebrate Homology

Qrsl1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: QRSL1
Gene Tree

Qrsl1

Diseases

1 with human QRSL1 associations

				Human Disease	Mouse Models
				combined oxidative phosphorylation deficiency 40 IDs combined oxidative phosphorylation deficiency 40 DOID:0112117 OMIM:618835 ORDO:570491

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

4
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Qrsl1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

18
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

1
cDNA Data

44
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase qrsl1

ZFIN qrsl1

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All Sequences

43
RefSeq

5
UniProt

1
CCDS

CCDS35894.1

Ensembl

ENSMUSG00000019863 (Evidence)
NCBI Gene

76563

			Length	Strain/Species	Flank
genomic	ENSMUSG00000019863	Ensembl Gene Model \| MGI Sequence Detail	27558	C57BL/6J	± kb
transcript	ENSMUST00000020012	Ensembl \| MGI Sequence Detail	1981	Not Applicable
polypeptide	ENSMUSP00000020012	Ensembl \| MGI Sequence Detail	525	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000013571 glutamyl-tRNA(Gln) amidotransferase subunit A

(term hierarchy)
EC

6.3.5.7
InterPro Domains

IPR000120 Amidase

IPR036928 Amidase signature (AS) superfamily

IPR023631 Amidase signature domain

IPR004412 Glutamyl-tRNA(Gln) amidotransferase A subunit
GlyGen

Q9CZN8 1 site, 1 N-linked glycan (1 site)

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All nucleic 45

cDNA 44

Primer pair 1

Microarray probesets 4

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MGI:2143931

Summaries

All 45

Developmental Gene Expression 2

Gene Ontology 7

Phenotypes 13
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Qrsl1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr97478	Chr10:43777708-43777748 (-)	13 bp
Tssr97477	Chr10:43777666-43777698 (-)	59 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/22/2024 MGI 6.24