Acsl3 MGI Mouse Gene Detail - MGI:1921455 - acyl-CoA synthetase long-chain family member 3

Symbol

Acsl3
Name

acyl-CoA synthetase long-chain family member 3
Synonyms

2610510B12Rik, C85929, Facl3

Feature Type

protein coding gene
IDs

MGI:1921455
NCBI Gene: 74205
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr1:78635600-78685462 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 40.84 cM
Mapping Data

4 experiments

SNPs within 2kb

676 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921455	protein coding gene	Chr1:78635542-78685462 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016201	protein coding gene	Chr1:79400333-79456192 (+)
A/J	MGP_AJ_G0016184	protein coding gene	Chr1:76621044-76670357 (+)
AKR/J	MGP_AKRJ_G0016141	protein coding gene	Chr1:78695881-78745858 (+)
BALB/cJ	MGP_BALBcJ_G0016139	protein coding gene	Chr1:76711048-76761213 (+)
C3H/HeJ	MGP_C3HHeJ_G0015969	protein coding gene	Chr1:79069597-79124261 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016592	protein coding gene	Chr1:82441033-82505412 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014312	protein coding gene	Chr1:72044350-72099056 (+)
CAST/EiJ	MGP_CASTEiJ_G0015554	protein coding gene	Chr1:78453901-78513418 (+)
CBA/J	MGP_CBAJ_G0015943	protein coding gene	Chr1:85168626-85225167 (+)
DBA/2J	MGP_DBA2J_G0016044	protein coding gene	Chr1:75933125-75987071 (+)
FVB/NJ	MGP_FVBNJ_G0016047	protein coding gene	Chr1:75091733-75141510 (+)
LP/J	MGP_LPJ_G0016116	protein coding gene	Chr1:80529804-80583537 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016067	protein coding gene	Chr1:88388803-88442436 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016639	protein coding gene	Chr1:78844910-78897292 (+)
PWK/PhJ	MGP_PWKPhJ_G0015340	protein coding gene	Chr1:75402641-75454393 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015118	protein coding gene	Chr1:78172817-78225727 (+)
WSB/EiJ	MGP_WSBEiJ_G0015615	protein coding gene	Chr1:78629898-78682657 (+)

Human Ortholog

ACSL3, acyl-CoA synthetase long chain family member 3

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ACSL3, acyl-CoA synthetase long chain family member 3
Synonyms

ACS3, FACL3, LACS 3, LACS3, PRO2194
Links

HGNC:3570

NCBI Gene ID: 2181

neXtProt AC: NX_O95573

UniProt: O95573
Chr Location

2q36.1; chr2:222860942-222944639 (+) GRCh38

MGI Vertebrate Homology

Acsl3 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ACSL3
Gene Tree

Acsl3

Diseases

3 with human ACSL3 associations

				Human Disease	Mouse Models
				asthma IDs asthma DOID:2841 DOID:12703 DOID:13829 DOID:13830 DOID:2840 DOID:5783 ICD10CM:J45 ICD9CM:493 ICD9CM:493.9 KEGG:05310 MESH:D001249 NCI:C28397 OMIM:600807 UMLS_CUI:C0004096
				breast cancer IDs breast cancer DOID:1612 DOID:1648 DOID:4241 ICD10CM:C50 ICD9CM:174.8 MESH:D001943 NCI:C9335 OMIM:114480 UMLS_CUI:C0006142
				prostate cancer IDs prostate cancer DOID:10283 DOID:514 ICD10CM:C61 ICD9CM:185 KEGG:05215 MESH:D011471 NCI:C3343 NCI:C7378 OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959 ORDO:1331 UMLS_CUI:C0033578 UMLS_CUI:C0376358

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

21
Chemically induced (other)

1
Endonuclease-mediated

6
Gene trapped

9
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Acsl3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

50 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mice exhibit decreased blood percentages of CD4 T cells and B cells, and a decreased IgG1 response to ovalbumin. Male mutant mice exhibit growth retardation, reduced size and reduced total tissue and lean body mass.

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All GO Annotations

44
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

829
Tissues

100
cDNA Data

11
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase acsl3

ZFIN acsl3a, acsl3b

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All Sequences

67
RefSeq

16
UniProt

3
CCDS

CCDS15087.1, CCDS48295.1

Ensembl

ENSMUSG00000032883 (Evidence)
NCBI Gene

74205

			Length	Strain/Species	Flank
genomic	74205	NCBI Gene Model \| MGI Sequence Detail	49863	C57BL/6J	± kb
transcript	NM_001409075	RefSeq \| MGI Sequence Detail	3972	ZRU/MplStud
polypeptide	Q9CZW4	UniProt \| EBI \| MGI Sequence Detail	720	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000003660 fatty acid CoA ligase Acsl3

(term hierarchy)
EC

6.2.1.15, 6.2.1.2, 6.2.1.3
InterPro Domains

IPR020845 AMP-binding, conserved site

IPR000873 AMP-dependent synthetase/ligase domain

IPR042099 ANL, N-terminal domain
GlyGen

Q9CZW4 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 13

cDNA 11

Primer pair 2

Microarray probesets 5

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MGI:2138711

Summaries

All 57

Developmental Gene Expression 6

Gene Ontology 8

Phenotypes 19
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:347631 Li C, et al., Cfp1 Controls Cardiomyocyte Maturation by Modifying Histone H3K4me3 of Structural, Metabolic, and Contractile Related Genes. Adv Sci (Weinh). 2024 Mar;11(11):e2305992

TSS for Acsl3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr7583	Chr1:78647228-78647247 (+)	11,638 bp
Tssr7584	Chr1:78651920-78651925 (+)	16,323 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/22/2024 MGI 6.24