Mdm1 MGI Mouse Gene Detail - MGI:96951

Symbol

Mdm1
Name

MDM1 nuclear protein
Synonyms

Mdm-1, transformed mouse 3T3 cell double minute 1

Feature Type

protein coding gene
IDs

MGI:96951
NCBI Gene: 17245
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr10:117977716-118004902 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 66.65 cM, cytoband C1-C3
Mapping Data

27 experiments

SNPs within 2kb

987 from dbSNP Build 142
Strain Annotations

18
RFLP

5

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96951	protein coding gene	Chr10:117977446-118004904 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017765	protein coding gene	Chr10:121141011-121173372 (+)
A/J	MGP_AJ_G0017740	protein coding gene	Chr10:116378802-116406759 (+)
AKR/J	MGP_AKRJ_G0017704	protein coding gene	Chr10:119795965-119823553 (+)
BALB/cJ	MGP_BALBcJ_G0017704	protein coding gene	Chr10:116768300-116795647 (+)
C3H/HeJ	MGP_C3HHeJ_G0017529	protein coding gene	Chr10:120017095-120044657 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018159	protein coding gene	Chr10:125278738-125306002 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015840	protein coding gene	Chr10:110917316-110945625 (+)
CAST/EiJ	MGP_CASTEiJ_G0017089	protein coding gene	Chr10:120319461-120346755 (+)
CBA/J	MGP_CBAJ_G0017498	protein coding gene	Chr10:130253036-130280600 (+)
DBA/2J	MGP_DBA2J_G0017603	protein coding gene	Chr10:115512656-115540467 (+)
FVB/NJ	MGP_FVBNJ_G0017597	protein coding gene	Chr10:114480095-114507301 (+)
LP/J	MGP_LPJ_G0017676	protein coding gene	Chr10:121673413-121701757 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017627	protein coding gene	Chr10:133074688-133103314 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018199	protein coding gene	Chr10:119842118-119869354 (+)
PWK/PhJ	MGP_PWKPhJ_G0016873	protein coding gene	Chr10:115608158-115636071 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016663	protein coding gene	Chr10:118769343-118796952 (+)
WSB/EiJ	MGP_WSBEiJ_G0017150	protein coding gene	Chr10:120046310-120073462 (+)

Human Ortholog

MDM1, Mdm1 nuclear protein

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MDM1, Mdm1 nuclear protein
Links

HGNC:29917

NCBI Gene ID: 56890

neXtProt AC: NX_Q8TC05

UniProt: Q8TC05
Chr Location

12q15; chr12:68272443-68332381 (-) GRCh38

MGI Vertebrate Homology

Mdm1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MDM1
Gene Tree

Mdm1

Diseases

1 with Mdm1 mouse models

Human Disease

Mouse Models

retinal degeneration

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

12 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Endonuclease-mediated

1
Spontaneous

1
Targeted

2
Genomic Mutations

1 involving Mdm1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a nonsense point mutation exhibit retinal degeneration, abnormal eye electrophysiology.

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All GO Annotations

24
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

713
Tissues

4
cDNA Data

15
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mdm1

ZFIN mdm1

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All Sequences

103
RefSeq

44
UniProt

8
CCDS

CCDS36069.1, CCDS48697.1, CCDS48698.1, CCDS48699.1

Ensembl

ENSMUSG00000020212 (Evidence)
NCBI Gene

17245

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020212	Ensembl Gene Model \| MGI Sequence Detail	27187	C57BL/6J	± kb
transcript	ENSMUST00000163238	Ensembl \| MGI Sequence Detail	2461	Not Applicable
polypeptide	ENSMUSP00000127919	Ensembl \| MGI Sequence Detail	718	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000010266 nuclear protein MDM1

(term hierarchy)
InterPro Domains

IPR029136 Nuclear protein MDM1

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All nucleic 20

Genomic 4

cDNA 16

Microarray probesets 4

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MGD-MRK-12168, MGD-MRK-12171

Summaries

All 55

Developmental Gene Expression 1

Diseases 1

Gene Ontology 11

Phenotypes 12
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Mdm1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr95938	Chr10:117977428-117977433 (+)	-285 bp
Tssr95939	Chr10:117977436-117977438 (+)	-279 bp
Tssr95940	Chr10:117977453-117977464 (+)	-257 bp
Tssr95941	Chr10:117977465-117977470 (+)	-248 bp
Tssr95942	Chr10:117977707-117977775 (+)	25 bp
Tssr95943	Chr10:117977790-117977803 (+)	81 bp
Tssr95944	Chr10:117977808-117977817 (+)	97 bp
Tssr95945	Chr10:117977822-117977833 (+)	112 bp
Tssr95946	Chr10:117992013-117992017 (+)	14,299 bp
Tssr3369	Chr10:117992502-117992504 (+)	14,787 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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