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Det1 Gene Detail
Summary
  • Symbol
    Det1
  • Name
    DET1 partner of COP1 E3 ubiquitin ligase
  • Synonyms
    2610034H20Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923625
    NCBI Gene: 76375
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:78471295-78497011 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 44.81 cM, cytoband D2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    574 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923625
 protein coding gene Chr7:78471293-78497272 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032380
 protein coding gene Chr7:80653372-80679852 (-)
A/J MGP_AJ_G0032359
 protein coding gene Chr7:78820441-78845403 (-)
AKR/J MGP_AKRJ_G0032295
 protein coding gene Chr7:80513219-80535955 (-)
BALB/cJ MGP_BALBcJ_G0032371
 protein coding gene Chr7:78517568-78542899 (-)
C3H/HeJ MGP_C3HHeJ_G0032084
 protein coding gene Chr7:81170011-81194500 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032863
 protein coding gene Chr7:83829409-83853309 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029871
 protein coding gene Chr7:81378530-81401352 (-)
CAST/EiJ MGP_CASTEiJ_G0031412
 protein coding gene Chr7:72011155-72035712 (-)
CBA/J MGP_CBAJ_G0032050
 protein coding gene Chr7:86610504-86648233 (-)
DBA/2J MGP_DBA2J_G0032205
 protein coding gene Chr7:77411131-77434260 (-)
FVB/NJ MGP_FVBNJ_G0032160
 protein coding gene Chr7:77307709-77330679 (-)
LP/J MGP_LPJ_G0032286
 protein coding gene Chr7:81902981-81925770 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032197
 protein coding gene Chr7:86870428-86896676 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032881
 protein coding gene Chr7:79950264-79974886 (-)
PWK/PhJ MGP_PWKPhJ_G0031132
 protein coding gene Chr7:70554580-70580596 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030973
 protein coding gene Chr7:66923855-66953129 (-)
WSB/EiJ MGP_WSBEiJ_G0031530
 protein coding gene Chr7:80267801-80294802 (-)



Homology
more
  • Human Ortholog
    DET1, DET1 partner of COP1 E3 ubiquitin ligase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DET1, DET1 partner of COP1 E3 ubiquitin ligase
  • Links
    NCBI Gene ID: 55070
    neXtProt AC: NX_Q7L5Y6
    UniProt: Q7L5Y6

  • Chr Location
    15q26.1; chr15:88494440-88546703 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    6
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030610 Ensembl Gene Model | MGI Sequence Detail 25717 C57BL/6J ±  kb
transcript ENSMUST00000032839 Ensembl | MGI Sequence Detail 2269 Not Applicable  
polypeptide ENSMUSP00000032839 Ensembl | MGI Sequence Detail 550 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 6
    cDNA 6

    Microarray probesets 3
References
more
  • Summaries
    All 39
    Gene Ontology 4
    Phenotypes 18
  • Earliest
    J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
  • Latest
    J:278856 Rizzini L, et al., Cryptochromes-Mediated Inhibition of the CRL4(Cop1)-Complex Assembly Defines an Evolutionary Conserved Signaling Mechanism. Curr Biol. 2019 Jun 17;29(12):1954-1962.e4
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory