Rars1 MGI Mouse Gene Detail - MGI:1914297 - arginyl-tRNA synthetase 1

Symbol

Rars1
Name

arginyl-tRNA synthetase 1
Synonyms

2610011N19Rik, 2610037E21Rik, Rars

Feature Type

protein coding gene
IDs

MGI:1914297
NCBI Gene: 104458
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr11:35699208-35725333 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 21.96 cM
Mapping Data

2 experiments

SNPs within 2kb

952 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914297	protein coding gene	Chr11:35699207-35725355 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018157	protein coding gene	Chr11:34219501-34249223 (-)
A/J	MGP_AJ_G0018130	protein coding gene	Chr11:32934978-32961126 (-)
AKR/J	MGP_AKRJ_G0018094	protein coding gene	Chr11:33926181-33952325 (-)
BALB/cJ	MGP_BALBcJ_G0018099	protein coding gene	Chr11:33098450-33124598 (-)
C3H/HeJ	MGP_C3HHeJ_G0017912	protein coding gene	Chr11:33886332-33912475 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018553	protein coding gene	Chr11:35259799-35285924 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016208	protein coding gene	Chr11:31387269-31416776 (-)
CAST/EiJ	MGP_CASTEiJ_G0017476	protein coding gene	Chr11:33870201-33898115 (-)
CBA/J	MGP_CBAJ_G0017885	protein coding gene	Chr11:36944817-36970965 (-)
DBA/2J	MGP_DBA2J_G0017995	protein coding gene	Chr11:32678634-32704777 (-)
FVB/NJ	MGP_FVBNJ_G0017989	protein coding gene	Chr11:32530306-32556423 (-)
LP/J	MGP_LPJ_G0018067	protein coding gene	Chr11:34429742-34455890 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018013	protein coding gene	Chr11:37672027-37699718 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018592	protein coding gene	Chr11:33952115-33978502 (-)
PWK/PhJ	MGP_PWKPhJ_G0017257	protein coding gene	Chr11:32766031-32792715 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017049	protein coding gene	Chr11:33718183-33746835 (-)
WSB/EiJ	MGP_WSBEiJ_G0017525	protein coding gene	Chr11:33724832-33750947 (-)

Human Ortholog

RARS1, arginyl-tRNA synthetase 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RARS1, arginyl-tRNA synthetase 1
Synonyms

ArgRS, DALRD1, HLD9, RARS
Links

HGNC:9870

NCBI Gene ID: 5917

neXtProt AC: NX_P54136

UniProt: P54136
Chr Location

5q34; chr5:168486451-168519301 (+) GRCh38

MGI Vertebrate Homology

Rars1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RARS1
Gene Tree

Rars1

Diseases

1 with human RARS1 associations

				Human Disease	Mouse Models
				hypomyelinating leukodystrophy 9 IDs hypomyelinating leukodystrophy 9 DOID:0060791 ICD10CM:E75.2 OMIM:616140 ORDO:438114

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

7
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Rars1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

33 strains or lines available

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All GO Annotations

27
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

894
Tissues

95
cDNA Data

249
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rars1

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All Sequences

51
RefSeq

4
UniProt

3
CCDS

CCDS24544.1

Ensembl

ENSMUSG00000018848 (Evidence)
NCBI Gene

104458

			Length	Strain/Species	Flank
genomic	ENSMUSG00000018848	Ensembl Gene Model \| MGI Sequence Detail	26126	C57BL/6J	± kb
transcript	ENSMUST00000018992	Ensembl \| MGI Sequence Detail	2109	Not Applicable
polypeptide	ENSMUSP00000018992	Ensembl \| MGI Sequence Detail	660	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000013742 arginine--tRNA ligase, cytoplasmic

(term hierarchy)
EC

6.1.1.19
InterPro Domains

IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-binding

IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site

IPR001278 Arginine-tRNA ligase

IPR035684 Arginyl-tRNA synthetase, catalytic core domain

IPR005148 Arginyl tRNA synthetase N-terminal domain

IPR036695 Arginyl tRNA synthetase N-terminal domain superfamily

IPR008909 DALR anticodon binding

IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
GlyGen

Q9D0I9 1 site, 1 O-linked glycan (1 site)

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All nucleic 251

cDNA 249

Primer pair 2

Microarray probesets 3

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MGI:1924077, MGI:2144362, MGI:2144591, MGI:7482291

Summaries

All 42

Developmental Gene Expression 2

Gene Ontology 7

Phenotypes 12
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Rars1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr107410	Chr11:35726854-35726855 (-)	-1,522 bp
Tssr107409	Chr11:35725345-35725357 (-)	-18 bp
Tssr107408	Chr11:35725319-35725336 (-)	5 bp
Tssr3463	Chr11:35725284-35725303 (-)	39 bp
Tssr3462	Chr11:35725201-35725209 (-)	128 bp
Tssr107407	Chr11:35724088-35724134 (-)	1,222 bp
Tssr107406	Chr11:35719518-35719543 (-)	5,802 bp
Tssr107405	Chr11:35719075-35719083 (-)	6,254 bp
Tssr107404	Chr11:35708265-35708273 (-)	17,064 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24