Cyc1 MGI Mouse Gene Detail - MGI:1913695

Symbol

Cyc1
Name

cytochrome c-1
Synonyms

2610002H19Rik, Cyct1

Feature Type

protein coding gene
IDs

MGI:1913695
NCBI Gene: 66445
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr15:76227723-76230460 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 35.74 cM
Mapping Data

2 experiments

SNPs within 2kb

81 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913695	protein coding gene	Chr15:76227711-76230460 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021985	protein coding gene	Chr15:76414665-76417076 (+)
A/J	MGP_AJ_G0021943	protein coding gene	Chr15:73631504-73633915 (+)
AKR/J	MGP_AKRJ_G0021926	protein coding gene	Chr15:75633166-75635577 (+)
BALB/cJ	MGP_BALBcJ_G0021952	protein coding gene	Chr15:73659242-73661653 (+)
C3H/HeJ	MGP_C3HHeJ_G0021724	protein coding gene	Chr15:75674801-75677249 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022392	protein coding gene	Chr15:79266709-79269802 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019921	protein coding gene	Chr15:70291905-70294310 (+)
CAST/EiJ	MGP_CASTEiJ_G0021243	protein coding gene	Chr15:76473530-76475941 (+)
CBA/J	MGP_CBAJ_G0021691	protein coding gene	Chr15:81775653-81778064 (+)
DBA/2J	MGP_DBA2J_G0021816	protein coding gene	Chr15:73167279-73169724 (+)
FVB/NJ	MGP_FVBNJ_G0021797	protein coding gene	Chr15:72217217-72219628 (+)
LP/J	MGP_LPJ_G0021887	protein coding gene	Chr15:76505012-76507423 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021821	protein coding gene	Chr15:87112238-87114649 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022412	protein coding gene	Chr15:75873096-75875507 (+)
PWK/PhJ	MGP_PWKPhJ_G0020984	protein coding gene	Chr15:73325291-73327702 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020824	protein coding gene	Chr15:75594398-75596809 (+)
WSB/EiJ	MGP_WSBEiJ_G0021295	protein coding gene	Chr15:75975993-75978404 (+)

Human Ortholog

CYC1, cytochrome c1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CYC1, cytochrome c1
Synonyms

MC3DN6, UQCR4
Links

HGNC:2579

NCBI Gene ID: 1537

neXtProt AC: NX_P08574

UniProt: P08574
Chr Location

8q24.3; chr8:144095039-144097525 (+) GRCh38

MGI Vertebrate Homology

Cyc1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CYC1
Gene Tree

Cyc1

Diseases

1 with human CYC1 associations

				Human Disease	Mouse Models
				mitochondrial complex III deficiency nuclear type 6 IDs mitochondrial complex III deficiency nuclear type 6 DOID:0080115 OMIM:615453

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

6 phenotypes from 1 allele in 2 genetic backgrounds
1 images
31 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

3
Endonuclease-mediated

1
Gene trapped

3
Radiation induced

2
Targeted

1
Genomic Mutations

5 involving Cyc1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele show small embryo size, embryonic growth retardation, abnormal epiblast and embryonic-extraembryonic boundary morphology, and complete embryonic lethality by E9.5.

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All GO Annotations

21
GO References

18

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

813
Tissues

101
cDNA Data

251
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cyc1

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All Sequences

68
RefSeq

4
UniProt

4
CCDS

CCDS27567.1

Ensembl

ENSMUSG00000022551 (Evidence)
NCBI Gene

66445

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022551	Ensembl Gene Model \| MGI Sequence Detail	2738	C57BL/6J	± kb
transcript	ENSMUST00000023210	Ensembl \| MGI Sequence Detail	1520	Not Applicable
polypeptide	ENSMUSP00000023210	Ensembl \| MGI Sequence Detail	325	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000006089 cytochrome c1, heme protein, mitochondrial

(term hierarchy)
PDB

7O37, 7O3C, 7O3E, 7O3H, 8PW5, 8PW6, 8PW7
EC

7.1.1.8
InterPro Domains

IPR002326 Cytochrome c1

IPR021157 Cytochrome c1, transmembrane anchor, C-terminal

IPR009056 Cytochrome c-like domain

IPR036909 Cytochrome c-like domain superfamily
GlyGen

Q9D0M3 1 site, 1 O-linked glycan (1 site)

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All nucleic 252

cDNA 251

Primer pair 1

Microarray probesets 2

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MGI:2145898

Summaries

All 75

Developmental Gene Expression 6

Diseases 1

Gene Ontology 18

Phenotypes 31
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:355679 Vercellino I, et al., SCAF1 drives the compositional diversity of mammalian respirasomes. Nat Struct Mol Biol. 2024 Jul;31(7):1061-1071

TSS for Cyc1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr131778	Chr15:76227704-76227758 (+)	8 bp
Tssr131779	Chr15:76227772-76227783 (+)	55 bp
Tssr131780	Chr15:76228580-76228595 (+)	865 bp
Tssr131781	Chr15:76228631-76228652 (+)	919 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24