Tmem219 MGI Mouse Gene Detail - MGI:1915992

Symbol

Tmem219
Name

transmembrane protein 219
Synonyms

1110032O16Rik, 2900045G02Rik

Feature Type

protein coding gene
IDs

MGI:1915992
NCBI Gene: 68742
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr7:126485343-126522089 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 69.25 cM, cytoband F4
Mapping Data

2 experiments

SNPs within 2kb

972 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915992	protein coding gene	Chr7:126485343-126527993 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0033007	protein coding gene	Chr7:131192465-131230822 (-)
A/J	MGP_AJ_G0032990	protein coding gene	Chr7:127712002-127750098 (-)
AKR/J	MGP_AKRJ_G0032922	protein coding gene	Chr7:130947298-130983708 (-)
BALB/cJ	MGP_BALBcJ_G0032995	protein coding gene	Chr7:127375521-127413190 (-)
C3H/HeJ	MGP_C3HHeJ_G0032705	protein coding gene	Chr7:130885460-130923782 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0033501	protein coding gene	Chr7:136292998-136337812 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030473	protein coding gene	Chr7:128905795-128946477 (-)
CAST/EiJ	MGP_CASTEiJ_G0032034	protein coding gene	Chr7:122671192-122710602 (-)
CBA/J	MGP_CBAJ_G0032678	protein coding gene	Chr7:140881791-140920476 (-)
DBA/2J	MGP_DBA2J_G0032830	protein coding gene	Chr7:125687552-125724884 (-)
FVB/NJ	MGP_FVBNJ_G0032783	protein coding gene	Chr7:125538698-125575230 (-)
LP/J	MGP_LPJ_G0032924	protein coding gene	Chr7:132658726-132697213 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032815	protein coding gene	Chr7:142050617-142092294 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033520	protein coding gene	Chr7:129957999-129995801 (-)
PWK/PhJ	MGP_PWKPhJ_G0031741	protein coding gene	Chr7:118682160-118719409 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0031587	protein coding gene	Chr7:116802522-116838815 (-)
WSB/EiJ	MGP_WSBEiJ_G0032146	protein coding gene	Chr7:130936284-130975406 (-)

Human Ortholog

TMEM219, transmembrane protein 219

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TMEM219, transmembrane protein 219
Synonyms

IGFBP-3R, IGFBP3R
Links

HGNC:25201

NCBI Gene ID: 124446

neXtProt AC: NX_Q86XT9

UniProt: Q86XT9
Chr Location

16p11.2; chr16:29940885-29973050 (+) GRCh38

MGI Vertebrate Homology

Tmem219 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TMEM219
Gene Tree

Tmem219

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References

3 with disease annotations

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Phenotype Summary

10 phenotypes from 1 allele in 1 genetic background
3 phenotypes from multigenic genotypes
44 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Endonuclease-mediated

1
Gene trapped

8
Targeted

7
Genomic Mutations

5 involving Tmem219
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

10 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit attenuated IL13 responsiveness, increased susceptibility to exposure to 100% oxygen, and reduced lung metastasis of B16-F10 melanoma cells.

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All GO Annotations

2
GO References

2

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

41

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

64
RefSeq

10
UniProt

7
CCDS

CCDS40133.1, CCDS90330.1

Ensembl

ENSMUSG00000060538 (Evidence)
NCBI Gene

68742

			Length	Strain/Species	Flank
genomic	ENSMUSG00000060538	Ensembl Gene Model \| MGI Sequence Detail	36747	C57BL/6J	± kb
transcript	ENSMUST00000120007	Ensembl \| MGI Sequence Detail	1087	Not Applicable
polypeptide	ENSMUSP00000113647	Ensembl \| MGI Sequence Detail	272	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000032707 transmembrane protein 219

(term hierarchy)
InterPro Domains

IPR039493 TMEM248/TMEM219

IPR039587 TMEM248/TMEM219 domain
GlyGen

Q9D123 1 site

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All nucleic 41

cDNA 41

Microarray probesets 5

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MGI:1920171

Summaries

All 69

Diseases 3

Gene Ontology 2

Phenotypes 44
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:349484 Henis M, et al., The autism susceptibility kinase, TAOK2, phosphorylates eEF2 and modulates translation. Sci Adv. 2024 Apr 12;10(15):eadf7001

TSS for Tmem219:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr74860	Chr7:126522059-126522098 (-)	10 bp
Tssr74859	Chr7:126522019-126522058 (-)	50 bp
Tssr74858	Chr7:126497421-126497460 (-)	24,648 bp
Tssr74857	Chr7:126497397-126497419 (-)	24,681 bp
Tssr74856	Chr7:126496685-126496697 (-)	25,398 bp
Tssr74855	Chr7:126496644-126496655 (-)	25,439 bp
Tssr74854	Chr7:126496534-126496587 (-)	25,528 bp
Tssr74853	Chr7:126496513-126496526 (-)	25,569 bp
Tssr74852	Chr7:126496405-126496416 (-)	25,678 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24