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Mrps25 Gene Detail
Summary
  • Symbol
    Mrps25
  • Name
    mitochondrial ribosomal protein S25
  • Synonyms
    2810429N01Rik, Rpms25
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928140
    NCBI Gene: 64658
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:92146506-92161014 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 41.03 cM, cytoband D3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    323 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1928140
 protein coding gene Chr6:92146493-92161014 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031056
 protein coding gene Chr6:93805531-93816551 (-)
A/J MGP_AJ_G0031025
 protein coding gene Chr6:90234396-90248708 (-)
AKR/J MGP_AKRJ_G0030956
 protein coding gene Chr6:92727246-92742600 (-)
BALB/cJ MGP_BALBcJ_G0031036
 protein coding gene Chr6:90194313-90209548 (-)
C3H/HeJ MGP_C3HHeJ_G0030672
 protein coding gene Chr6:91688102-91704049 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031495
 protein coding gene Chr6:96221665-96231516 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028662
 protein coding gene Chr6:88207541-88225503 (-)
CAST/EiJ MGP_CASTEiJ_G0030143
 protein coding gene Chr6:92860955-92873877 (-)
CBA/J MGP_CBAJ_G0030722
 protein coding gene Chr6:99800087-99811308 (-)
DBA/2J MGP_DBA2J_G0030875
 protein coding gene Chr6:89408584-89423471 (-)
FVB/NJ MGP_FVBNJ_G0030829
 protein coding gene Chr6:88626501-88639613 (-)
LP/J MGP_LPJ_G0030955
 protein coding gene Chr6:93754925-93767872 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030863
 protein coding gene Chr6:103836693-103852004 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031522
 protein coding gene Chr6:92581871-92594965 (-)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0029688
 protein coding gene Chr6:91496768-91506027 (-)
WSB/EiJ MGP_WSBEiJ_G0030227
 protein coding gene Chr6:93050817-93064699 (-)



Homology
more
  • Human Ortholog
    MRPS25, mitochondrial ribosomal protein S25
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MRPS25, mitochondrial ribosomal protein S25
  • Synonyms
    COXPD50, MRP-S25, mS25, RPMS25
  • Links
    NCBI Gene ID: 64432
    neXtProt AC: NX_P82663
    UniProt: P82663

  • Chr Location
    3p25.1; chr3:15009611-15065339 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human MRPS25 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 1 allele in 2 genetic backgrounds
    1 images
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic growth retardation, failure of primitive streak formation, disorganized extraembryonic tissue, and complete embryonic lethality by E9.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    807
  • Tissues
    76
  • cDNA Data
    10
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000014551 Ensembl Gene Model | MGI Sequence Detail 14509 C57BL/6J ±  kb
    transcript ENSMUST00000140438 Ensembl | MGI Sequence Detail 6073 Not Applicable  
    polypeptide ENSMUSP00000114402 Ensembl | MGI Sequence Detail 171 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 10
      Primer pair 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1913713
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 7
      Gene Ontology 9
      Phenotypes 17
    • Earliest
      J:65180 Redkar AA, et al., Genes in the first and fourth inversions of the mouse t complex synergistically mediate sperm capacitation and interactions with the oocyte. Dev Biol. 2000 Oct 15;226(2):267-80
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory