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Mcee Gene Detail
Summary
  • Symbol
    Mcee
  • Name
    methylmalonyl CoA epimerase
  • Synonyms
    1110007A04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920974
    NCBI Gene: 73724
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:64042370-64061869 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 34.65 cM, cytoband C
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    687 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920974
 protein coding gene Chr7:64042355-64061873 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032338
 protein coding gene Chr7:65534068-65555110 (+)
A/J MGP_AJ_G0032317
 protein coding gene Chr7:64262909-64282522 (+)
AKR/J MGP_AKRJ_G0032253
 protein coding gene Chr7:65622006-65641452 (+)
BALB/cJ MGP_BALBcJ_G0032329
 protein coding gene Chr7:64002961-64022599 (+)
C3H/HeJ MGP_C3HHeJ_G0032042
 protein coding gene Chr7:66269237-66288705 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032822
 protein coding gene Chr7:68356196-68383539 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029829
 protein coding gene Chr7:67210527-67231127 (+)
CAST/EiJ MGP_CASTEiJ_G0031371
 protein coding gene Chr7:56965739-56986707 (+)
CBA/J MGP_CBAJ_G0032008
 protein coding gene Chr7:70560507-70581045 (+)
DBA/2J MGP_DBA2J_G0032164
 protein coding gene Chr7:63014833-63033620 (+)
FVB/NJ MGP_FVBNJ_G0032118
 protein coding gene Chr7:63113725-63133813 (+)
LP/J MGP_LPJ_G0032244
 protein coding gene Chr7:66776466-66797416 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032155
 protein coding gene Chr7:70832426-70852561 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032839
 protein coding gene Chr7:64904028-64926466 (+)
PWK/PhJ MGP_PWKPhJ_G0031091
 protein coding gene Chr7:56024682-56043940 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030932
 protein coding gene Chr7:52044603-52070525 (+)
WSB/EiJ MGP_WSBEiJ_G0031489
 protein coding gene Chr7:65286034-65311395 (+)



Homology
more
  • Human Ortholog
    MCEE, methylmalonyl-CoA epimerase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MCEE, methylmalonyl-CoA epimerase
  • Synonyms
    GLOD2, MCE, MMCE
  • Links
    NCBI Gene ID: 84693
    neXtProt AC: NX_Q96PE7
    UniProt: Q96PE7

  • Chr Location
    2p13.3; chr2:71109684-71130239 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotype references
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    3
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Mcee
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    15 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    801
  • Tissues
    94
  • cDNA Data
    33
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 73724 NCBI Gene Model | MGI Sequence Detail 19500 C57BL/6J ±  kb
transcript NM_028626 RefSeq | MGI Sequence Detail 847 C57BL/6  
polypeptide Q9D1I5 UniProt | EBI | MGI Sequence Detail 178 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000010235 methylmalonyl-CoA epimerase, mitochondrial
    (term hierarchy)
  • EC
    5.1.99.1
  • InterPro Domains
    IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
    IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain
    IPR017515 Methylmalonyl-CoA epimerase
    IPR051785 Methylmalonyl-CoA/ethylmalonyl-CoA epimerase
    IPR037523 Vicinal oxygen chelate (VOC) domain
  • GlyGen
    Q9D1I5 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 33
    cDNA 33

    Microarray probesets 2
References
more
  • Summaries
    All 41
    Developmental Gene Expression 2
    Gene Ontology 8
    Phenotypes 13
  • Earliest
    J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
  • Latest
    J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory