Eef1e1 MGI Mouse Gene Detail - MGI:1913393 - eukaryotic translation elongation factor 1 epsilon 1

Symbol

Eef1e1
Name

eukaryotic translation elongation factor 1 epsilon 1
Synonyms

1110003A02Rik, AIMP3

Feature Type

protein coding gene
IDs

MGI:1913393
NCBI Gene: 66143
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr13:38829667-38843004 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 18.38 cM, cytoband A5
Mapping Data

2 experiments

SNPs within 2kb

430 from dbSNP Build 142
Strain Annotations

16

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913393	protein coding gene	Chr13:38828183-38843034 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020475	protein coding gene	Chr13:37010961-37025536 (-)
A/J	MGP_AJ_G0020429	protein coding gene	Chr13:35824460-35837616 (-)
AKR/J	MGP_AKRJ_G0020407	protein coding gene	Chr13:36777787-36790874 (-)
BALB/cJ	MGP_BALBcJ_G0020425	protein coding gene	Chr13:35926206-35939362 (-)
C3H/HeJ	MGP_C3HHeJ_G0020224	protein coding gene	Chr13:36611068-36624206 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020858	protein coding gene	Chr13:38217754-38230862 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018445	protein coding gene	Chr13:34010167-34021039 (-)
CAST/EiJ	MGP_CASTEiJ_G0019739	protein coding gene	Chr13:36392171-36402824 (-)
CBA/J	MGP_CBAJ_G0020185	protein coding gene	Chr13:39837569-39850726 (-)
DBA/2J	MGP_DBA2J_G0020307	protein coding gene	Chr13:35343498-35356661 (-)
FVB/NJ	MGP_FVBNJ_G0020286	protein coding gene	Chr13:34873043-34886171 (-)
LP/J	MGP_LPJ_G0020382	protein coding gene	Chr13:37253843-37266974 (-)
NOD/ShiLtJ	no annotation
NZO/HlLtJ	MGP_NZOHlLtJ_G0020901	protein coding gene	Chr13:36341254-36354402 (-)
PWK/PhJ	MGP_PWKPhJ_G0019494	protein coding gene	Chr13:35471756-35484974 (-)
SPRET/EiJ	no annotation
WSB/EiJ	MGP_WSBEiJ_G0019801	protein coding gene	Chr13:36702102-36715241 (-)

Human Ortholog

EEF1E1, eukaryotic translation elongation factor 1 epsilon 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

EEF1E1, eukaryotic translation elongation factor 1 epsilon 1
Synonyms

AIMP3, P18
Links

HGNC:3212

NCBI Gene ID: 9521

neXtProt AC: NX_O43324

UniProt: O43324
Chr Location

6p24.3; chr6:8073360-8102559 (-) GRCh38

MGI Vertebrate Homology

Eef1e1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: EEF1E1
Gene Tree

Eef1e1

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Chemically induced (other)

1
Gene trapped

15
Targeted

1
Genomic Mutations

1 involving Eef1e1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

19 strains or lines available

Mice homozygous for a gene trap allele display early embryonic lethality while heterozygous mice exhibit prenatal semi-lethality and a significantly increased incidence of spontaneous tumorigenesis after 15 months of age.

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All GO Annotations

25
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

756
Tissues

33
cDNA Data

45
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase eef1e1

ZFIN eef1e1

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All Sequences

35
RefSeq

2
UniProt

2
CCDS

CCDS26465.1

Ensembl

ENSMUSG00000001707 (Evidence)
NCBI Gene

66143

			Length	Strain/Species	Flank
genomic	66143	NCBI Gene Model \| MGI Sequence Detail	13338	C57BL/6J	± kb
transcript	NM_025380	RefSeq \| MGI Sequence Detail	1039	C57BL/6
polypeptide	Q9D1M4	UniProt \| EBI \| MGI Sequence Detail	174	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000006907 eukaryotic translation elongation factor 1 epsilon-1

(term hierarchy)
InterPro Domains

IPR042450 Eukaryotic translation elongation factor 1 epsilon-1

IPR036282 Glutathione S-transferase, C-terminal domain superfamily

IPR010987 Glutathione S-transferase, C-terminal-like

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All nucleic 46

cDNA 45

Primer pair 1

Microarray probesets 3

Summaries

All 40

Developmental Gene Expression 3

Gene Ontology 8

Phenotypes 11
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:274587 Kotov DI, et al., TCR Affinity Biases Th Cell Differentiation by Regulating CD25, Eef1e1, and Gbp2. J Immunol. 2019 May 1;202(9):2535-2545

TSS for Eef1e1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr122141	Chr13:38842967-38843014 (-)	13 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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