Misp MGI Mouse Gene Detail - MGI:1926156 - mitotic spindle positioning

Symbol

Misp
Name

mitotic spindle positioning
Synonyms

9130017N09Rik

Feature Type

protein coding gene
IDs

MGI:1926156
NCBI Gene: 78906
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr10:79656853-79666286 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.72 cM, cytoband C1
Mapping Data

2 experiments

SNPs within 2kb

286 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1926156	protein coding gene	Chr10:79656823-79666324 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017462	protein coding gene	Chr10:80371425-80380655 (+)
A/J	MGP_AJ_G0017440	protein coding gene	Chr10:77575085-77584423 (+)
AKR/J	MGP_AKRJ_G0017401	protein coding gene	Chr10:79684110-79695768 (+)
BALB/cJ	MGP_BALBcJ_G0017402	protein coding gene	Chr10:77801534-77811219 (+)
C3H/HeJ	MGP_C3HHeJ_G0017225	protein coding gene	Chr10:79790939-79801360 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017856	protein coding gene	Chr10:83143488-83152673 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015544	protein coding gene	Chr10:73805827-73811429 (+)
CAST/EiJ	MGP_CASTEiJ_G0016792	protein coding gene	Chr10:79974900-79984513 (+)
CBA/J	MGP_CBAJ_G0017197	protein coding gene	Chr10:86367227-86379822 (+)
DBA/2J	MGP_DBA2J_G0017303	protein coding gene	Chr10:76789735-76799110 (+)
FVB/NJ	MGP_FVBNJ_G0017297	protein coding gene	Chr10:75968168-75977732 (+)
LP/J	MGP_LPJ_G0017374	protein coding gene	Chr10:80851042-80863339 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017323	protein coding gene	Chr10:88347541-88356961 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017897	protein coding gene	Chr10:79669977-79680434 (+)
PWK/PhJ	MGP_PWKPhJ_G0016573	protein coding gene	Chr10:76649962-76659806 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016362	protein coding gene	Chr10:78641645-78651564 (+)
WSB/EiJ	MGP_WSBEiJ_G0016852	protein coding gene	Chr10:79692777-79703437 (+)

Human Ortholog

MISP, mitotic spindle positioning

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MISP, mitotic spindle positioning
Synonyms

C19orf21, MISP1
Links

HGNC:27000

NCBI Gene ID: 126353

neXtProt AC: NX_Q8IVT2

UniProt: Q8IVT2
Chr Location

19p13.3; chr19:748438-764318 (+) GRCh38

MGI Vertebrate Homology

Misp stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MISP
Gene Tree

Misp

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Phenotype Summary

11 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

2
Targeted

4
Genomic Mutations

1 involving Misp
Incidental Mutations

Mutagenetix
Find Mice (IMSR)

20 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit exacerbated dextran sulfate sodium (DSS)-induced colitis with significant increases in weight loss, more severe symptoms (bloody stools and diarrhea), and extensive crypt loss.

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All GO Annotations

30
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

780
Tissues

7
cDNA Data

42
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

54
RefSeq

14
UniProt

3
CCDS

CCDS23992.1

Ensembl

ENSMUSG00000035852 (Evidence)
NCBI Gene

78906

			Length	Strain/Species	Flank
genomic	78906	NCBI Gene Model \| MGI Sequence Detail	9434	C57BL/6J	± kb
transcript	NM_030218	RefSeq \| MGI Sequence Detail	2427	C57BL/6
polypeptide	Q9D279	UniProt \| EBI \| MGI Sequence Detail	648	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000059910 mitotic interactor and substrate of PLK1

(term hierarchy)
InterPro Domains

IPR029304 A-kinase anchor protein 2, C-terminal domain

IPR042779 MISP/MISP3-like

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All nucleic 42

cDNA 42

Microarray probesets 2

Summaries

All 35

Developmental Gene Expression 2

Gene Ontology 4

Phenotypes 12
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:333842 Hiura K, et al., Mitotic spindle positioning protein (MISP) deficiency exacerbates dextran sulfate sodium (DSS)-induced colitis in mice. J Vet Med Sci. 2023 Feb 1;85(2):167-174

TSS for Misp:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr94402	Chr10:79656840-79656863 (+)	-1 bp
Tssr94403	Chr10:79658451-79658513 (+)	1,629 bp
Tssr94404	Chr10:79660422-79660452 (+)	3,584 bp
Tssr94405	Chr10:79660507-79660529 (+)	3,665 bp
Tssr94406	Chr10:79660538-79660554 (+)	3,693 bp
Tssr94407	Chr10:79661840-79661857 (+)	4,996 bp
Tssr94408	Chr10:79661952-79661972 (+)	5,109 bp
Tssr94409	Chr10:79662148-79662154 (+)	5,298 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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