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Desi2 Gene Detail
Summary
  • Symbol
    Desi2
  • Name
    desumoylating isopeptidase 2
  • Synonyms
    5830417C01Rik, Fam152a, Pppde1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926075
    NCBI Gene: 78825
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:178014983-178080164 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 82.93 cM, cytoband H3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    778 from dbSNP Build 142
  • Strain Annotations
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926075
 protein coding gene Chr1:178014983-178084867 (+)
129S1/SvImJ no annotation
A/J MGP_AJ_G0016830
 protein coding gene Chr1:177019026-177092958 (+)
AKR/J MGP_AKRJ_G0016796
 protein coding gene Chr1:182306867-182377019 (+)
BALB/cJ MGP_BALBcJ_G0016788
 protein coding gene Chr1:177354750-177748264 (+)
C3H/HeJ MGP_C3HHeJ_G0016613
 protein coding gene Chr1:183046220-183126327 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017252
 protein coding gene Chr1:190226614-190537279 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014959
 protein coding gene Chr1:168066388-168121225 (+)
CAST/EiJ MGP_CASTEiJ_G0016194
 protein coding gene Chr1:182325828-182411753 (+)
CBA/J MGP_CBAJ_G0016587
 protein coding gene Chr1:197228881-197606115 (+)
DBA/2J MGP_DBA2J_G0016693
 protein coding gene Chr1:175898088-175967387 (+)
FVB/NJ MGP_FVBNJ_G0016689
 protein coding gene Chr1:173980487-174047058 (+)
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0016720
 protein coding gene Chr1:204414917-204805557 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017288
 protein coding gene Chr1:181850335-182109002 (+)
PWK/PhJ MGP_PWKPhJ_G0015982
 protein coding gene Chr1:175007405-175027614 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015758
 protein coding gene Chr1:180736999-181049910 (+)
WSB/EiJ MGP_WSBEiJ_G0016257
 protein coding gene Chr1:182249270-182323055 (+)



Homology
more
  • Human Ortholog
    DESI2, desumoylating isopeptidase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DESI2, desumoylating isopeptidase 2
  • Synonyms
    C1orf121, CGI-146, DESI, DESI1, DeSI-2, FAM152A, PNAS-4, PPPDE1
  • Links
    NCBI Gene ID: 51029
    neXtProt AC: NX_Q9BSY9
    UniProt: Q9BSY9

  • Chr Location
    1q44; chr1:244653103-244709033 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    8 phenotype references
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    2
  • Gene trapped
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Desi2
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    25 strains or lines available
Mice homozygous for a knock-out mouse exhibit normal body size, body weight, brain size, brain weight and neuron apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    746
  • Tissues
    32
  • cDNA Data
    69
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 78825 NCBI Gene Model | MGI Sequence Detail 65182 C57BL/6J ±  kb
transcript NM_024282 RefSeq | MGI Sequence Detail 4214 C57BL/6  
polypeptide Q9D291 UniProt | EBI | MGI Sequence Detail 194 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 69
    cDNA 69

    Microarray probesets 5
References
more
  • Summaries
    All 37
    Developmental Gene Expression 2
    Gene Ontology 9
    Phenotypes 8
  • Earliest
    J:61896 Lee YJ, et al., Mit1/Lb9 and Copg2, new members of mouse imprinted genes closely linked to Peg1/Mest(1). FEBS Lett. 2000 Apr 28;472(2-3):230-4
  • Latest
    J:310009 He Y, et al., Comprehensive analysis of expression profile reveals the ubiquitous distribution of PPPDE peptidase domain 1, a Golgi apparatus component, and its implications in clinical cancer. Biochimie. 2013 Jul;95(7):1466-75
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory