Sp2 MGI Mouse Gene Detail - MGI:1926162 - Sp2 transcription factor

Symbol

Sp2
Name

Sp2 transcription factor

Feature Type

protein coding gene
IDs

MGI:1926162
NCBI Gene: 78912
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr11:96844167-96873785 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 60.17 cM, cytoband D
Mapping Data

2 experiments

SNPs within 2kb

777 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1926162	protein coding gene	Chr11:96844158-96873785 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019018	protein coding gene	Chr11:99326813-99356485 (-)
A/J	MGP_AJ_G0018986	protein coding gene	Chr11:95261573-95285849 (-)
AKR/J	MGP_AKRJ_G0018956	protein coding gene	Chr11:98214499-98238958 (-)
BALB/cJ	MGP_BALBcJ_G0018959	protein coding gene	Chr11:95747473-95778213 (-)
C3H/HeJ	MGP_C3HHeJ_G0018773	protein coding gene	Chr11:98327299-98351640 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019411	protein coding gene	Chr11:102409870-102441394 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017042	protein coding gene	Chr11:92724127-92753759 (-)
CAST/EiJ	MGP_CASTEiJ_G0018326	protein coding gene	Chr11:99175198-99201262 (-)
CBA/J	MGP_CBAJ_G0018744	protein coding gene	Chr11:106611077-106635347 (-)
DBA/2J	MGP_DBA2J_G0018852	protein coding gene	Chr11:94811461-94841755 (-)
FVB/NJ	MGP_FVBNJ_G0018841	protein coding gene	Chr11:94289088-94318585 (-)
LP/J	MGP_LPJ_G0018922	protein coding gene	Chr11:99847268-99872586 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018868	protein coding gene	Chr11:106541355-106573274 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019451	protein coding gene	Chr11:98503034-98536132 (-)
PWK/PhJ	MGP_PWKPhJ_G0018098	protein coding gene	Chr11:95781757-95811430 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017888	protein coding gene	Chr11:98233444-98258841 (-)
WSB/EiJ	MGP_WSBEiJ_G0018376	protein coding gene	Chr11:98415038-98445687 (-)

Human Ortholog

SP2, Sp2 transcription factor

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SP2, Sp2 transcription factor
Links

HGNC:11207

NCBI Gene ID: 6668

neXtProt AC: NX_Q02086

UniProt: Q02086
Chr Location

17q21.32; chr17:47896150-47931731 (+) GRCh38

MGI Vertebrate Homology

Sp2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SP2
Gene Tree

Sp2

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Phenotype Summary

28 phenotypes from 4 alleles in 4 genetic backgrounds
2 images
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

156
Gene trapped

148
Targeted

8
Genomic Mutations

1 involving Sp2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

151 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

No homozygous null mice survived beyond E10.5, with decrease embryo size and embryonic growth retardation starting at E7.5.

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All GO Annotations

18
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

763
Tissues

57
cDNA Data

13
Literature Summary

11

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sp2

ZFIN sp2

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All Sequences

58
RefSeq

12
UniProt

6
CCDS

CCDS36291.1, CCDS88237.1

Ensembl

ENSMUSG00000018678 (Evidence)
NCBI Gene

78912

			Length	Strain/Species	Flank
genomic	ENSMUSG00000018678	Ensembl Gene Model \| MGI Sequence Detail	29619	C57BL/6J	± kb
transcript	ENSMUST00000107624	Ensembl \| MGI Sequence Detail	3055	Not Applicable
polypeptide	ENSMUSP00000103250	Ensembl \| MGI Sequence Detail	613	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000015440 transcription factor Sp2

(term hierarchy)
InterPro Domains

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type
GlyGen

Q9D2H6 6 sites, 1 O-linked glycan (6 sites)

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All nucleic 14

cDNA 13

Primer pair 1

Microarray probesets 3

Summaries

All 56

Developmental Gene Expression 11

Gene Ontology 6

Phenotypes 19
Earliest

J:33331 Nishiguchi S, et al., A catalogue of genes in mouse embryonal carcinoma F9 cells identified with expressed sequence tags. J Biochem. 1996 Apr;119(4):749-67
Latest

J:285048 Johnson CA, et al., Sp2 regulates late neurogenic but not early expansive divisions of neural stem cells underlying population growth in the mouse cortex. Development. 2020 Feb 21;147(4):dev186056

TSS for Sp2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr110379	Chr11:96868486-96868519 (-)	5,282 bp
Tssr110378	Chr11:96868171-96868210 (-)	5,594 bp
Tssr110377	Chr11:96868116-96868154 (-)	5,650 bp
Tssr110376	Chr11:96859531-96859544 (-)	14,247 bp
Tssr110375	Chr11:96859481-96859499 (-)	14,295 bp
Tssr110374	Chr11:96847049-96847062 (-)	26,729 bp
Tssr110373	Chr11:96847019-96847047 (-)	26,752 bp
Tssr110372	Chr11:96846790-96846801 (-)	26,989 bp
Tssr110371	Chr11:96846745-96846783 (-)	27,021 bp
Tssr110370	Chr11:96844558-96844570 (-)	29,221 bp
Tssr110369	Chr11:96844514-96844537 (-)	29,259 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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