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Amtn Gene Detail
Summary
  • Symbol
    Amtn
  • Name
    amelotin
  • Synonyms
    5430427O21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918671
    NCBI Gene: 71421
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr5:88523967-88533775 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 43.56 cM, cytoband E2
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    364 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918671
 protein coding gene Chr5:88523967-88533775 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029705
 protein coding gene Chr5:89389051-89398909 (+)
A/J MGP_AJ_G0029671
 protein coding gene Chr5:85843513-85853321 (+)
AKR/J MGP_AKRJ_G0029617
 protein coding gene Chr5:88669642-88679451 (+)
BALB/cJ MGP_BALBcJ_G0029681
 protein coding gene Chr5:86751384-86761246 (+)
C3H/HeJ MGP_C3HHeJ_G0029404
 protein coding gene Chr5:89034854-89044712 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030135
 protein coding gene Chr5:93012448-93023435 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027371
 protein coding gene Chr5:81672909-81684284 (+)
CAST/EiJ MGP_CASTEiJ_G0028814
 protein coding gene Chr5:88461455-88472143 (+)
CBA/J MGP_CBAJ_G0029373
 protein coding gene Chr5:96103565-96113233 (+)
DBA/2J MGP_DBA2J_G0029518
 protein coding gene Chr5:85914067-85923718 (+)
FVB/NJ MGP_FVBNJ_G0029477
 protein coding gene Chr5:84854555-84864363 (+)
LP/J MGP_LPJ_G0029606
 protein coding gene Chr5:89776636-89786352 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029506
 protein coding gene Chr5:101128657-101142241 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030169
 protein coding gene Chr5:88222256-88232148 (+)
PWK/PhJ MGP_PWKPhJ_G0028533
 protein coding gene Chr5:85006830-85016691 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028368
 protein coding gene Chr5:87624374-87636037 (+)
WSB/EiJ MGP_WSBEiJ_G0028893
 protein coding gene Chr5:88592913-88604528 (+)



Homology
more
  • Human Ortholog
    AMTN, amelotin
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AMTN, amelotin
  • Synonyms
    AI3B, UNQ689
  • Links
    NCBI Gene ID: 401138
    neXtProt AC: NX_Q6UX39
    UniProt: Q6UX39

  • Chr Location
    4q13.3; chr4:70518569-70532743 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human AMTN associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit enamel hypomineralization.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    8
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    710
  • Tissues
    1
  • cDNA Data
    4
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 71421 NCBI Gene Model | MGI Sequence Detail 9809 C57BL/6J ±  kb
    transcript NM_027793 RefSeq | MGI Sequence Detail 1022 C57BL/6  
    polypeptide Q9D3J8 UniProt | EBI | MGI Sequence Detail 213 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 4
      cDNA 4

      Microarray probesets 2
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 4
      Gene Ontology 8
      Phenotypes 17
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory