Tasl MGI Mouse Gene Detail - MGI:1918648 - TLR adaptor interacting with endolysosomal SLC15A4

Symbol

Tasl
Name

TLR adaptor interacting with endolysosomal SLC15A4
Synonyms

5430427O19Rik

Feature Type

protein coding gene
IDs

MGI:1918648
NCBI Gene: 71398
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

ChrX:84913960-84935105 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 39.39 cM, cytoband B
Mapping Data

2 experiments

SNPs within 2kb

615 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918648	protein coding gene	ChrX:84820445-84935105 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035890	protein coding gene	ChrX:81957013-81977873 (+)
A/J	MGP_AJ_G0035875	protein coding gene	ChrX:82061074-82083061 (+)
AKR/J	MGP_AKRJ_G0035793	protein coding gene	ChrX:84243419-84266549 (+)
BALB/cJ	MGP_BALBcJ_G0035856	protein coding gene	ChrX:80786795-80810458 (+)
C3H/HeJ	MGP_C3HHeJ_G0035566	protein coding gene	ChrX:82253723-82275307 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0036387	protein coding gene	ChrX:84457134-84481355 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033218	protein coding gene	ChrX:80935748-80958004 (+)
CAST/EiJ	MGP_CASTEiJ_G0034855	protein coding gene	ChrX:67217824-67238516 (+)
CBA/J	MGP_CBAJ_G0035541	protein coding gene	ChrX:86752497-86773372 (+)
DBA/2J	MGP_DBA2J_G0035696	protein coding gene	ChrX:81447344-81468552 (+)
FVB/NJ	MGP_FVBNJ_G0035635	protein coding gene	ChrX:80855600-80876716 (+)
LP/J	MGP_LPJ_G0035785	protein coding gene	ChrX:82755056-82777916 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035672	protein coding gene	ChrX:90264944-90291608 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036414	protein coding gene	ChrX:81663734-81687642 (+)
PWK/PhJ	MGP_PWKPhJ_G0034553	protein coding gene	ChrX:65241036-65262206 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0034383	protein coding gene	ChrX:68159284-68179617 (+)
WSB/EiJ	MGP_WSBEiJ_G0034994	protein coding gene	ChrX:80578229-80599098 (+)

Human Ortholog

TASL, TLR adaptor interacting with endolysosomal SLC15A4

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TASL, TLR adaptor interacting with endolysosomal SLC15A4
Synonyms

CXorf21
Links

HGNC:25667

NCBI Gene ID: 80231

neXtProt AC: NX_Q9HAI6

UniProt: Q9HAI6
Chr Location

Xp21.2; chrX:30558809-30577766 (-) GRCh38

MGI Vertebrate Homology

Tasl stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: TASL
Gene Tree

Tasl

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Phenotype Summary

4 phenotype references

All Mutations and Alleles

4
Endonuclease-mediated

2
Targeted

2
Incidental Mutations

APF
Find Mice (IMSR)

7 strains or lines available

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All GO Annotations

16
GO References

6

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

8

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

39
RefSeq

7
UniProt

2
CCDS

CCDS53127.1

Ensembl

ENSMUSG00000025058 (Evidence)
NCBI Gene

71398

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025058	Ensembl Gene Model \| MGI Sequence Detail	21146	C57BL/6J	± kb
transcript	ENSMUST00000113976	Ensembl \| MGI Sequence Detail	3754	Not Applicable
polypeptide	ENSMUSP00000109609	Ensembl \| MGI Sequence Detail	298	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000060096 TLR adapter interacting with SLC15A4 on the lysosome

(term hierarchy)
InterPro Domains

IPR027869 TASL protein

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All nucleic 8

cDNA 8

Microarray probesets 3

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MGI:6449853

Summaries

All 30

Gene Ontology 6

Phenotypes 4
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Tasl:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr161445	ChrX:84913827-84913857 (+)	-118 bp
Tssr161446	ChrX:84913872-84913903 (+)	-72 bp
Tssr161447	ChrX:84913930-84913941 (+)	-24 bp
Tssr161448	ChrX:84913984-84913995 (+)	30 bp
Tssr161449	ChrX:84914311-84914319 (+)	355 bp
Tssr161450	ChrX:84915329-84915334 (+)	1,372 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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