Cep72 MGI Mouse Gene Detail - MGI:1921720

Symbol

Cep72
Name

centrosomal protein 72
Synonyms

2610029E11Rik, 4933440J22Rik

Feature Type

protein coding gene
IDs

MGI:1921720
NCBI Gene: 74470
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr13:74184619-74210418 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 40.15 cM, cytoband C1
Mapping Data

2 experiments

SNPs within 2kb

657 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921720	protein coding gene	Chr13:74184351-74210439 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020758	protein coding gene	Chr13:74528905-74554695 (-)
A/J	MGP_AJ_G0020714	protein coding gene	Chr13:71862378-71889096 (-)
AKR/J	MGP_AKRJ_G0020688	protein coding gene	Chr13:74114432-74141611 (-)
BALB/cJ	MGP_BALBcJ_G0020711	protein coding gene	Chr13:72357764-72383554 (-)
C3H/HeJ	MGP_C3HHeJ_G0020505	protein coding gene	Chr13:73801787-73828495 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021148	protein coding gene	Chr13:77004855-77030625 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018715	protein coding gene	Chr13:68685598-68713102 (-)
CAST/EiJ	MGP_CASTEiJ_G0020022	protein coding gene	Chr13:72876627-72903929 (-)
CBA/J	MGP_CBAJ_G0020464	protein coding gene	Chr13:79862167-79892444 (-)
DBA/2J	MGP_DBA2J_G0020589	protein coding gene	Chr13:71681476-71707266 (-)
FVB/NJ	MGP_FVBNJ_G0020569	protein coding gene	Chr13:70706973-70732749 (-)
LP/J	MGP_LPJ_G0020662	protein coding gene	Chr13:74765472-74791259 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020597	protein coding gene	Chr13:78271151-78298126 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021187	protein coding gene	Chr13:73436912-73463352 (-)
PWK/PhJ	MGP_PWKPhJ_G0019776	protein coding gene	Chr13:70421391-70448993 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019599	protein coding gene	Chr13:69913492-69939442 (-)
WSB/EiJ	MGP_WSBEiJ_G0020080	protein coding gene	Chr13:73988962-74014685 (-)

Human Ortholog

CEP72, centrosomal protein 72

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CEP72, centrosomal protein 72
Links

HGNC:25547

NCBI Gene ID: 55722

neXtProt AC: NX_Q9P209

UniProt: Q9P209
Chr Location

5p15.33; chr5:612340-676616 (+) GRCh38

MGI Vertebrate Homology

Cep72 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CEP72
Gene Tree

Cep72

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Phenotype Summary

12 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

1
Genomic Mutations

1 involving Cep72
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

27 strains or lines available

Mice homozygous for a null allele are viable and exhibit normal fertility in both sexes; however, sperm appear morphologically abnormal with aberrant heads and flagellum structures.

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All GO Annotations

19
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

10

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

64
RefSeq

16
UniProt

5
CCDS

CCDS26639.1

Ensembl

ENSMUSG00000021572 (Evidence)
NCBI Gene

74470

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021572	Ensembl Gene Model \| MGI Sequence Detail	25800	C57BL/6J	± kb
transcript	ENSMUST00000036456	Ensembl \| MGI Sequence Detail	3641	Not Applicable
polypeptide	ENSMUSP00000037788	Ensembl \| MGI Sequence Detail	646	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000005356 centrosomal protein of 72 kDa

(term hierarchy)
InterPro Domains

IPR001611 Leucine-rich repeat

IPR032675 Leucine-rich repeat domain superfamily

IPR003591 Leucine-rich repeat, typical subtype

IPR003603 U2A'/phosphoprotein 32 family A, C-terminal
GlyGen

Q9D3R3 1 site, 1 O-linked glycan (1 site)

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All nucleic 10

cDNA 10

Microarray probesets 3

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MGI:1916499

Summaries

All 35

Gene Ontology 6

Phenotypes 9
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cep72:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr123206	Chr13:74210381-74210434 (-)	10 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24