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Tubgcp4 Gene Detail
Summary
  • Symbol
    Tubgcp4
  • Name
    tubulin, gamma complex component 4
  • Synonyms
    4932441P04Rik, D2Ertd435e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196293
    NCBI Gene: 51885
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:121001135-121029251 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 60.37 cM, cytoband F1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    526 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1196293
 protein coding gene Chr2:121001124-121029251 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026384
 protein coding gene Chr2:124055148-124083480 (+)
A/J MGP_AJ_G0026345
 protein coding gene Chr2:118979203-119007647 (+)
AKR/J MGP_AKRJ_G0026324
 protein coding gene Chr2:122324592-122352500 (+)
BALB/cJ MGP_BALBcJ_G0026358
 protein coding gene Chr2:119216990-119245589 (+)
C3H/HeJ MGP_C3HHeJ_G0026104
 protein coding gene Chr2:122803513-122832256 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026805
 protein coding gene Chr2:128119085-128150633 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024185
 protein coding gene Chr2:114025917-114053607 (+)
CAST/EiJ MGP_CASTEiJ_G0025566
 protein coding gene Chr2:123123225-123153340 (+)
CBA/J MGP_CBAJ_G0026080
 protein coding gene Chr2:132591867-132620966 (+)
DBA/2J MGP_DBA2J_G0026219
 protein coding gene Chr2:118380410-118408498 (+)
FVB/NJ MGP_FVBNJ_G0026181
 protein coding gene Chr2:117199625-117228061 (+)
LP/J MGP_LPJ_G0026320
 protein coding gene Chr2:124314150-124343101 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026200
 protein coding gene Chr2:136879204-136907204 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026860
 protein coding gene Chr2:122438203-122467893 (+)
PWK/PhJ MGP_PWKPhJ_G0025302
 protein coding gene Chr2:117985307-118013994 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025101
 protein coding gene Chr2:121655450-121684993 (+)
WSB/EiJ MGP_WSBEiJ_G0025635
 protein coding gene Chr2:123268475-123297261 (+)



Homology
more
  • Human Ortholog
    TUBGCP4, tubulin gamma complex component 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TUBGCP4, tubulin gamma complex component 4
  • Synonyms
    76P, GCP-4, GCP4, Grip76, MCCRP3
  • Links
    NCBI Gene ID: 27229
    neXtProt AC: NX_Q9UGJ1
    UniProt: Q9UGJ1

  • Chr Location
    15q15.3; chr15:43369221-43409771 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TUBGCP4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 2 alleles in 2 genetic backgrounds
    1 images
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice show complete embryonic lethality by E7.5. In vitro outgrowth assays show that blastocysts fail to hatch from the zona pellucida. Heterozygous mice show photoreceptor degeneration and retinopathy due to disrupted autophagy homeostasis in the retina.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    751
  • Tissues
    17
  • cDNA Data
    16
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027263 Ensembl Gene Model | MGI Sequence Detail 28117 C57BL/6J ±  kb
    transcript ENSMUST00000039541 Ensembl | MGI Sequence Detail 4206 Not Applicable  
    polypeptide ENSMUSP00000044049 Ensembl | MGI Sequence Detail 667 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000016829 gamma-tubulin complex component 4
      (term hierarchy)
    • InterPro Domains
      IPR040457 Gamma tubulin complex component, C-terminal
      IPR042241 Gamma-tubulin complex component, C-terminal domain superfamily
      IPR007259 Gamma-tubulin complex component protein
      IPR041470 Gamma tubulin complex component protein, N-terminal
    • GlyGen
      Q9D4F8 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 19
      Primer pair 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1921645
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 10
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory