Etnk1 MGI Mouse Gene Detail - MGI:1922570

Symbol

Etnk1
Name

ethanolamine kinase 1
Synonyms

1110061E11Rik, 4930555L11Rik, D6Ertd3e, EKI1

Feature Type

protein coding gene
IDs

MGI:1922570
NCBI Gene: 75320
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr6:143112592-143154272 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 75.41 cM
Mapping Data

4 experiments

SNPs within 2kb

1182 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1922570	protein coding gene	Chr6:143112592-143178033 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031473	protein coding gene	Chr6:148007177-148076343 (+)
A/J	MGP_AJ_G0031448	protein coding gene	Chr6:142191041-142256912 (+)
AKR/J	MGP_AKRJ_G0031376	protein coding gene	Chr6:146414218-146479203 (+)
BALB/cJ	MGP_BALBcJ_G0031455	protein coding gene	Chr6:141958136-142023732 (+)
C3H/HeJ	MGP_C3HHeJ_G0031177	protein coding gene	Chr6:146443001-146510669 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0031917	protein coding gene	Chr6:152050833-152117540 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029041	protein coding gene	Chr6:140998057-141063285 (+)
CAST/EiJ	MGP_CASTEiJ_G0030545	protein coding gene	Chr6:146046199-146116793 (+)
CBA/J	MGP_CBAJ_G0031137	protein coding gene	Chr6:157838041-157907945 (+)
DBA/2J	MGP_DBA2J_G0031294	protein coding gene	Chr6:141012222-141077529 (+)
FVB/NJ	MGP_FVBNJ_G0031245	protein coding gene	Chr6:139755957-139823642 (+)
LP/J	MGP_LPJ_G0031378	protein coding gene	Chr6:148145657-148212181 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031285	protein coding gene	Chr6:161710895-161783783 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031949	protein coding gene	Chr6:146263102-146329295 (+)
PWK/PhJ	MGP_PWKPhJ_G0030272	protein coding gene	Chr6:139497854-139565257 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030096	protein coding gene	Chr6:144434130-144509180 (+)
WSB/EiJ	MGP_WSBEiJ_G0030638	protein coding gene	Chr6:146851708-146918150 (+)

Human Ortholog

ETNK1, ethanolamine kinase 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ETNK1, ethanolamine kinase 1
Synonyms

EKI, EKI 1, EKI1, Nbla10396
Links

HGNC:24649

NCBI Gene ID: 55500

neXtProt AC: NX_Q9HBU6

UniProt: Q9HBU6
Chr Location

12p12.1; chr12:22625075-22690665 (+) GRCh38

MGI Vertebrate Homology

Etnk1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ETNK1
Gene Tree

Etnk1

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

26
Endonuclease-mediated

2
Gene trapped

21
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

33 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

10
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

807
Tissues

25
cDNA Data

24
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase etnk1

ZFIN etnk1

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All Sequences

64
RefSeq

7
UniProt

5
CCDS

CCDS57468.1

Ensembl

ENSMUSG00000030275 (Evidence)
NCBI Gene

75320

			Length	Strain/Species	Flank
genomic	75320	NCBI Gene Model \| MGI Sequence Detail	41681	C57BL/6J	± kb
transcript	NM_029250	RefSeq \| MGI Sequence Detail	6447	ZRU/MplStud
polypeptide	Q9D4V0	UniProt \| EBI \| MGI Sequence Detail	363	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000007219 ethanolamine kinase 1

(term hierarchy)
EC

2.7.1.82
InterPro Domains

IPR011009 Protein kinase-like domain superfamily

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All nucleic 30

cDNA 25

Primer pair 4

Other 1

Microarray probesets 8

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MGI:1098799, MGI:1353584, MGI:1916076, MGI:2141483, MGI:2141764

Summaries

All 57

Developmental Gene Expression 6

Gene Ontology 7

Phenotypes 16
Earliest

J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Etnk1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr59499	Chr6:143112936-143112993 (+)	373 bp
Tssr59500	Chr6:143112997-143113026 (+)	420 bp
Tssr59501	Chr6:143115651-143115655 (+)	3,061 bp
Tssr59502	Chr6:143117168-143117181 (+)	4,583 bp
Tssr59503	Chr6:143129043-143129046 (+)	16,453 bp
Tssr59504	Chr6:143149686-143149702 (+)	37,102 bp
Tssr59505	Chr6:143149751-143149764 (+)	37,166 bp
Tssr59506	Chr6:143151963-143151999 (+)	39,389 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24