Adad2 MGI Mouse Gene Detail - MGI:1923023 - adenosine deaminase domain containing 2

Symbol

Adad2
Name

adenosine deaminase domain containing 2
Synonyms

4930403J07Rik

Feature Type

protein coding gene
IDs

MGI:1923023
NCBI Gene: 75773
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr8:120339486-120343663 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 68.05 cM, cytoband E1
Mapping Data

2 experiments

SNPs within 2kb

280 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1923023	protein coding gene	Chr8:120339449-120343665 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034188	protein coding gene	Chr8:122951710-122958392 (+)
A/J	MGP_AJ_G0034168	protein coding gene	Chr8:117887130-117891310 (+)
AKR/J	MGP_AKRJ_G0034095	protein coding gene	Chr8:121311214-121315394 (+)
BALB/cJ	MGP_BALBcJ_G0034162	protein coding gene	Chr8:118091283-118095463 (+)
C3H/HeJ	MGP_C3HHeJ_G0033873	protein coding gene	Chr8:122037029-122041209 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034682	protein coding gene	Chr8:127061959-127066139 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031624	protein coding gene	Chr8:110781998-110786469 (+)
CAST/EiJ	MGP_CASTEiJ_G0033200	protein coding gene	Chr8:121981013-121987158 (+)
CBA/J	MGP_CBAJ_G0033846	protein coding gene	Chr8:131685379-131689559 (+)
DBA/2J	MGP_DBA2J_G0034002	protein coding gene	Chr8:117107101-117111281 (+)
FVB/NJ	MGP_FVBNJ_G0033945	protein coding gene	Chr8:116138265-116142445 (+)
LP/J	MGP_LPJ_G0034091	protein coding gene	Chr8:123091958-123096138 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033992	protein coding gene	Chr8:134128201-134132412 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034700	protein coding gene	Chr8:121462501-121466681 (+)
PWK/PhJ	MGP_PWKPhJ_G0032902	protein coding gene	Chr8:116861428-116865744 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032742	protein coding gene	Chr8:120155133-120159363 (+)
WSB/EiJ	MGP_WSBEiJ_G0033316	protein coding gene	Chr8:122179388-122183577 (+)

Human Ortholog

ADAD2, adenosine deaminase domain containing 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ADAD2, adenosine deaminase domain containing 2
Synonyms

TENRL
Links

HGNC:30714

NCBI Gene ID: 161931

neXtProt AC: NX_Q8NCV1

UniProt: Q8NCV1
Chr Location

16q24.1; chr16:84191138-84197168 (+) GRCh38

MGI Vertebrate Homology

Adad2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ADAD2
Gene Tree

Adad2

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Phenotype Summary

18 phenotypes from 6 alleles in 6 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

6
Gene trapped

1
Targeted

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for mutations of this gene exhibit male infertility associated with arrested spermiogenesis and instability of P-bodies.

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All GO Annotations

13
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

773
Tissues

33
cDNA Data

4
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase adad2

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All Sequences

31
RefSeq

6
UniProt

1
CCDS

CCDS52683.1

Ensembl

ENSMUSG00000024266 (Evidence)
NCBI Gene

75773

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024266	Ensembl Gene Model \| MGI Sequence Detail	4178	C57BL/6J	± kb
transcript	ENSMUST00000098361	Ensembl \| MGI Sequence Detail	1926	Not Applicable
polypeptide	ENSMUSP00000095964	Ensembl \| MGI Sequence Detail	561	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000031078 adenosine deaminase domain-containing protein 2

(term hierarchy)
InterPro Domains

IPR002466 Adenosine deaminase/editase

IPR014720 Double-stranded RNA-binding domain

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All nucleic 6

cDNA 4

Primer pair 2

Microarray probesets 2

Summaries

All 29

Developmental Gene Expression 2

Gene Ontology 4

Phenotypes 11
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Adad2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr79705	Chr8:120339440-120339471 (+)	-30 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24