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Mrpl2 Gene Detail
Summary
  • Symbol
    Mrpl2
  • Name
    mitochondrial ribosomal protein L2
  • Synonyms
    CGI-22, MRP-L14, Rpml14
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351622
    NCBI Gene: 27398
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:46957155-46961065 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 22.90 cM, cytoband C
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    164 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351622
 protein coding gene Chr17:46957094-46961065 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023823
 protein coding gene Chr17:47723505-47727400 (+)
A/J MGP_AJ_G0023781
 protein coding gene Chr17:46577908-46581804 (+)
AKR/J MGP_AKRJ_G0023752
 protein coding gene Chr17:46921472-46925368 (+)
BALB/cJ MGP_BALBcJ_G0023785
 protein coding gene Chr17:46478691-46482593 (+)
C3H/HeJ MGP_C3HHeJ_G0023548
 protein coding gene Chr17:47667054-47670950 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024228
 protein coding gene Chr17:49773564-49777460 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021678
 protein coding gene Chr17:43359797-43363793 (+)
CAST/EiJ MGP_CASTEiJ_G0023030
 protein coding gene Chr17:47751010-47754899 (+)
CBA/J MGP_CBAJ_G0023525
 protein coding gene Chr17:51567522-51571418 (+)
DBA/2J MGP_DBA2J_G0023651
 protein coding gene Chr17:45348735-45352642 (+)
FVB/NJ MGP_FVBNJ_G0023618
 protein coding gene Chr17:44970794-44974690 (+)
LP/J MGP_LPJ_G0023732
 protein coding gene Chr17:48403831-48407726 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023647
 protein coding gene Chr17:51112944-51116838 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024273
 protein coding gene Chr17:47275655-47279551 (+)
PWK/PhJ MGP_PWKPhJ_G0022775
 protein coding gene Chr17:44688732-44693010 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022590
 protein coding gene Chr17:44143588-44147508 (+)
WSB/EiJ MGP_WSBEiJ_G0023095
 protein coding gene Chr17:47830863-47835671 (+)



Homology
more
  • Human Ortholog
    MRPL2, mitochondrial ribosomal protein L2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MRPL2, mitochondrial ribosomal protein L2
  • Synonyms
    CGI-22, MRP-L14, RPML14, uL2m
  • Links
    NCBI Gene ID: 51069
    neXtProt AC: NX_Q5T653
    UniProt: Q5T653

  • Chr Location
    6p21.1; chr6:43054029-43059863 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype reference
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    720
  • Tissues
    13
  • cDNA Data
    99
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000002767 Ensembl Gene Model | MGI Sequence Detail 3911 C57BL/6J ±  kb
transcript ENSMUST00000002844 Ensembl | MGI Sequence Detail 1031 Not Applicable  
polypeptide ENSMUSP00000002844 Ensembl | MGI Sequence Detail 306 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000010582 large ribosomal subunit protein uL2m
    (term hierarchy)
  • InterPro Domains
    IPR002171 Large ribosomal subunit protein uL2
    IPR022669 Large ribosomal subunit protein uL2, C-terminal
    IPR014722 Large ribosomal subunit protein uL2, domain 2
    IPR022666 Large ribosomal subunit protein uL2, RNA-binding domain
    IPR012340 Nucleic acid-binding, OB-fold
    IPR008991 Translation protein SH3-like domain superfamily
Molecular
Reagents
less
  • All nucleic 101
    cDNA 100
    Primer pair 1

    Microarray probesets 4
References
more
  • Summaries
    All 29
    Developmental Gene Expression 1
    Gene Ontology 8
    Phenotypes 1
  • Earliest
    J:58917 O'Brien TW, et al., Mammalian mitochondrial ribosomal proteins (2). Amino acid sequencing, characterization, and identification of corresponding gene sequences. J Biol Chem. 1999 Dec 17;274(51):36043-51
  • Latest
    J:297050 Cheong A, et al., Expression analysis of mammalian mitochondrial ribosomal protein genes. Gene Expr Patterns. 2020 Sep 25;38:119147
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory