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Gpx8 Gene Detail
Summary
  • Symbol
    Gpx8
  • Name
    glutathione peroxidase 8 (putative)
  • Synonyms
    2310016C16Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916840
    NCBI Gene: 69590
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:113179287-113182944 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 63.93 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    148 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916840
 protein coding gene Chr13:113179287-113182944 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020947
 protein coding gene Chr13:115649891-115655003 (-)
A/J MGP_AJ_G0020897
 protein coding gene Chr13:111023342-111026949 (-)
AKR/J MGP_AKRJ_G0020872
 protein coding gene Chr13:114373484-114377116 (-)
BALB/cJ MGP_BALBcJ_G0020897
 protein coding gene Chr13:111718992-111722716 (-)
C3H/HeJ MGP_C3HHeJ_G0020686
 protein coding gene Chr13:114166080-114169745 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021333
 protein coding gene Chr13:119071224-119076670 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018902
 protein coding gene Chr13:106314089-106317715 (-)
CAST/EiJ MGP_CASTEiJ_G0020205
 protein coding gene Chr13:113805859-113809467 (-)
CBA/J MGP_CBAJ_G0020648
 protein coding gene Chr13:123677723-123681442 (-)
DBA/2J MGP_DBA2J_G0020771
 protein coding gene Chr13:110734852-110739129 (-)
FVB/NJ MGP_FVBNJ_G0020755
 protein coding gene Chr13:109436096-109439703 (-)
LP/J MGP_LPJ_G0020847
 protein coding gene Chr13:115683538-115687161 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020783
 protein coding gene Chr13:123932071-123936644 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021369
 protein coding gene Chr13:113838964-113842571 (-)
PWK/PhJ MGP_PWKPhJ_G0019959
 protein coding gene Chr13:109487516-109491109 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019781
 protein coding gene Chr13:110153627-110157267 (-)
WSB/EiJ MGP_WSBEiJ_G0020263
 protein coding gene Chr13:114435654-114439303 (-)



Homology
more
  • Human Ortholog
    GPX8, glutathione peroxidase 8 (putative)
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GPX8, glutathione peroxidase 8 (putative)
  • Synonyms
    EPLA847, GPx-8, GSHPx-8, UNQ847
  • Links
    NCBI Gene ID: 493869
    neXtProt AC: NX_Q8TED1
    UniProt: Q8TED1

  • Chr Location
    5q11.2; chr5:55160167-55167297 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male homozygous mice exhibit chronic active dermatitis, with epodermal hyperplasia and hyperkeratosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1046
  • Tissues
    111
  • cDNA Data
    34
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 69590 NCBI Gene Model | MGI Sequence Detail 3658 C57BL/6J ±  kb
    transcript NM_027127 RefSeq | MGI Sequence Detail 1048 C57BL/6  
    polypeptide Q9D7B7 UniProt | EBI | MGI Sequence Detail 209 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 35
      cDNA 34
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2145340
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 6
      Gene Ontology 7
      Phenotypes 6
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory