Cox20 MGI Mouse Gene Detail - MGI:1913609 - cytochrome c oxidase assembly protein 20

Symbol

Cox20
Name

cytochrome c oxidase assembly protein 20
Synonyms

2310005N03Rik, Fam36a

Feature Type

protein coding gene
IDs

MGI:1913609
NCBI Gene: 66359
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr1:178146695-178150258 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 83.16 cM, cytoband H3
Mapping Data

2 experiments

SNPs within 2kb

150 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913609	protein coding gene	Chr1:178146379-178150258 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016853	protein coding gene	Chr1:184604625-184608297 (+)
A/J	MGP_AJ_G0016831	protein coding gene	Chr1:177179597-177183135 (+)
AKR/J	MGP_AKRJ_G0016797	protein coding gene	Chr1:182460371-182463911 (+)
BALB/cJ	MGP_BALBcJ_G0016789	protein coding gene	Chr1:177813148-177816711 (+)
C3H/HeJ	MGP_C3HHeJ_G0016614	protein coding gene	Chr1:183193699-183197262 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017253	protein coding gene	Chr1:190609740-190613303 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014960	protein coding gene	Chr1:168189176-168192684 (+)
CAST/EiJ	MGP_CASTEiJ_G0016195	protein coding gene	Chr1:182477952-182481485 (+)
CBA/J	MGP_CBAJ_G0016588	protein coding gene	Chr1:197698120-197701683 (+)
DBA/2J	MGP_DBA2J_G0016694	protein coding gene	Chr1:176036638-176040201 (+)
FVB/NJ	MGP_FVBNJ_G0016690	protein coding gene	Chr1:174114327-174117865 (+)
LP/J	MGP_LPJ_G0016768	protein coding gene	Chr1:185881082-185884645 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016721	protein coding gene	Chr1:204871839-204875402 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017289	protein coding gene	Chr1:182175720-182179258 (+)
PWK/PhJ	MGP_PWKPhJ_G0015983	protein coding gene	Chr1:175090578-175094110 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015759	protein coding gene	Chr1:181129144-181132673 (+)
WSB/EiJ	MGP_WSBEiJ_G0016258	protein coding gene	Chr1:182398606-182402144 (+)

Human Ortholog

COX20, cytochrome c oxidase assembly factor COX20

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

COX20, cytochrome c oxidase assembly factor COX20
Synonyms

FAM36A, MC4DN11
Links

HGNC:26970

NCBI Gene ID: 116228

neXtProt AC: NX_Q5RI15

UniProt: Q5RI15
Chr Location

1q44; chr1:244835306-244845063 (+) GRCh38

MGI Vertebrate Homology

Cox20 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: COX20
Gene Tree

Cox20

Diseases

1 with human COX20 associations

				Human Disease	Mouse Models
				mitochondrial complex IV deficiency nuclear type 11 IDs mitochondrial complex IV deficiency nuclear type 11 DOID:0070497 OMIM:619054 UMLS_CUI:C5436694

Click on a disease name to see all genes associated with that disease.

less

Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

2
Endonuclease-mediated

1
Gene trapped

4
Genomic Mutations

2 involving Cox20
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

less

All GO Annotations

8
GO References

4

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

26

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cox20

ZFIN cox20

less

All Sequences

38
RefSeq

6
UniProt

1
CCDS

CCDS15556.1

Ensembl

ENSMUSG00000026500 (Evidence)
NCBI Gene

66359

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026500	Ensembl Gene Model \| MGI Sequence Detail	3564	C57BL/6J	± kb
transcript	ENSMUST00000027781	Ensembl \| MGI Sequence Detail	471	Not Applicable
polypeptide	ENSMUSP00000027781	Ensembl \| MGI Sequence Detail	117	Not Applicable

less

UniProt

1 Sequence
Protein Ontology

PR:000030199 cytochrome c oxidase assembly protein COX20, mitochondrial

(term hierarchy)
InterPro Domains

IPR022533 Cox20

less

All nucleic 27

cDNA 27

Microarray probesets 4

Summaries

All 35

Gene Ontology 4

Phenotypes 10
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cox20:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr10378	Chr1:178146375-178146430 (+)	-292 bp
Tssr10379	Chr1:178146692-178146703 (+)	3 bp
Tssr10380	Chr1:178146707-178146736 (+)	27 bp
Tssr10381	Chr1:178146834-178146854 (+)	149 bp
Tssr10382	Chr1:178146893-178146904 (+)	204 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24