Rpl22l1 MGI Mouse Gene Detail - MGI:1915278 - ribosomal protein L22 like 1

Symbol

Rpl22l1
Name

ribosomal protein L22 like 1
Synonyms

3110001N18Rik

Feature Type

protein coding gene
IDs

MGI:1915278
NCBI Gene: 68028
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr3:28859660-28861573 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 12.27 cM
Mapping Data

2 experiments

SNPs within 2kb

153 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915278	protein coding gene	Chr3:28859585-28861573 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027118	protein coding gene	Chr3:26200233-26205321 (+)
A/J	MGP_AJ_G0027078	protein coding gene	Chr3:25927505-25929493 (+)
AKR/J	MGP_AKRJ_G0027047	protein coding gene	Chr3:26311615-26313603 (+)
BALB/cJ	MGP_BALBcJ_G0027090	protein coding gene	Chr3:25629720-25633458 (+)
C3H/HeJ	MGP_C3HHeJ_G0026832	protein coding gene	Chr3:26348204-26350192 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027535	protein coding gene	Chr3:27593791-27595779 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024897	protein coding gene	Chr3:23944885-23946878 (+)
CAST/EiJ	MGP_CASTEiJ_G0026286	protein coding gene	Chr3:26202832-26204820 (+)
CBA/J	MGP_CBAJ_G0026810	protein coding gene	Chr3:28352557-28354545 (+)
DBA/2J	MGP_DBA2J_G0026944	protein coding gene	Chr3:25510143-25512362 (+)
FVB/NJ	MGP_FVBNJ_G0026911	protein coding gene	Chr3:24965750-24968182 (+)
LP/J	MGP_LPJ_G0027055	protein coding gene	Chr3:26893805-26896894 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026932	protein coding gene	Chr3:30889396-30906158 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027595	protein coding gene	Chr3:26052157-26054624 (+)
PWK/PhJ	MGP_PWKPhJ_G0026019	protein coding gene	Chr3:24991263-24993367 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025831	protein coding gene	Chr3:25589343-25591390 (+)
WSB/EiJ	MGP_WSBEiJ_G0026360	protein coding gene	Chr3:26100253-26102566 (+)

Human Ortholog

RPL22L1, ribosomal protein L22 like 1

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RPL22L1, ribosomal protein L22 like 1
Links

HGNC:27610

NCBI Gene ID: 200916

neXtProt AC: NX_Q6P5R6

UniProt: Q6P5R6
Chr Location

3q26.2; chr3:170864875-170870208 (-) GRCh38

MGI Vertebrate Homology

Rpl22l1 stringent orthology
1 human;1 mouse;3 rat;1 zebrafish
HCOP

vertebrate homology predictions: RPL22L1
Gene Tree

Rpl22l1

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References

1 with disease annotations

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Gene trapped

4
Radiation induced

1
Targeted

2
Genomic Mutations

1 involving Rpl22l1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit abnormal development at E9.5 and die by E12.5.

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All GO Annotations

7
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

10

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rpl22l1

ZFIN rpl22l1

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All Sequences

55
RefSeq

6
UniProt

3
CCDS

CCDS17278.1, CCDS84615.1

Ensembl

ENSMUSG00000039221 (Evidence)
NCBI Gene

68028

			Length	Strain/Species	Flank
genomic	68028	NCBI Gene Model \| MGI Sequence Detail	1914	C57BL/6J	± kb
transcript	NR_154888	RefSeq \| MGI Sequence Detail	553	C57BL/6
polypeptide	Q9D7S7	UniProt \| EBI \| MGI Sequence Detail	122	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000014202 ribosomal protein eL22-like

(term hierarchy)
InterPro Domains

IPR002671 Large ribosomal subunit protein eL22

IPR038526 Large ribosomal subunit protein eL22 superfamily

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All nucleic 10

cDNA 10

Microarray probesets 5

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MGI:2139906

Summaries

All 29

Diseases 1

Gene Ontology 3

Phenotypes 7
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:322243 Fahl SP, et al., Loss of Ribosomal Protein Paralog Rpl22-like1 Blocks Lymphoid Development without Affecting Protein Synthesis. J Immunol. 2022 Feb 15;208(4):870-880

TSS for Rpl22l1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr28661	Chr3:28859647-28859670 (+)	-1 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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