Chmp5 MGI Mouse Gene Detail - MGI:1924209 - charged multivesicular body protein 5

Symbol

Chmp5
Name

charged multivesicular body protein 5
Synonyms

2210412K09Rik, chromatin modifying protein 5

Feature Type

protein coding gene
IDs

MGI:1924209
NCBI Gene: 76959
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr4:40948553-40965302 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 20.69 cM
Mapping Data

2 experiments

SNPs within 2kb

520 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1924209	protein coding gene	Chr4:40948407-40965303 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028151	protein coding gene	Chr4:38859087-38880400 (+)
A/J	MGP_AJ_G0028109	protein coding gene	Chr4:37392135-37408976 (+)
AKR/J	MGP_AKRJ_G0028072	protein coding gene	Chr4:38348780-38366772 (+)
BALB/cJ	MGP_BALBcJ_G0028121	protein coding gene	Chr4:37722869-37739951 (+)
C3H/HeJ	MGP_C3HHeJ_G0027849	protein coding gene	Chr4:38889244-38907923 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028562	protein coding gene	Chr4:40292034-40308869 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025903	protein coding gene	Chr4:35044861-35061844 (+)
CAST/EiJ	MGP_CASTEiJ_G0027305	protein coding gene	Chr4:38544297-38560913 (+)
CBA/J	MGP_CBAJ_G0027821	protein coding gene	Chr4:41665808-41684707 (+)
DBA/2J	MGP_DBA2J_G0027965	protein coding gene	Chr4:37311595-37328507 (+)
FVB/NJ	MGP_FVBNJ_G0027932	protein coding gene	Chr4:36646822-36663623 (+)
LP/J	MGP_LPJ_G0028073	protein coding gene	Chr4:38926858-38945428 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027965	protein coding gene	Chr4:44999609-45016973 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028621	protein coding gene	Chr4:38462746-38480376 (+)
PWK/PhJ	MGP_PWKPhJ_G0027024	protein coding gene	Chr4:37316199-37333299 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026851	protein coding gene	Chr4:38156261-38175419 (+)
WSB/EiJ	MGP_WSBEiJ_G0027381	protein coding gene	Chr4:38417411-38434076 (+)

Human Ortholog

CHMP5, charged multivesicular body protein 5

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CHMP5, charged multivesicular body protein 5
Synonyms

C9orf83, CGI-34, HSPC177, PNAS-2, SNF7DC2, Spike, Vps60
Links

HGNC:26942

NCBI Gene ID: 51510

neXtProt AC: NX_Q9NZZ3

UniProt: Q9NZZ3
Chr Location

9p13.3; chr9:33264879-33282070 (+) GRCh38

MGI Vertebrate Homology

Chmp5 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CHMP5
Gene Tree

Chmp5

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Phenotype Summary

12 phenotypes from 1 allele in 1 genetic background
1 images
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically and radiation induced

1
Endonuclease-mediated

4
Gene trapped

3
Targeted

3
Genomic Mutations

1 involving Chmp5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice display embryonic lethality during organogenesis, cardia bifida, impaired chorioallantoic fusion, abnormal somite and neural plate devlopment, accumulation of multivesicular bodies, and impaired endocytosis.

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All GO Annotations

68
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

709
Tissues

3
cDNA Data

119
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase chmp5

ZFIN chmp5b

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All Sequences

34
RefSeq

2
UniProt

1
CCDS

CCDS18053.1

Ensembl

ENSMUSG00000028419 (Evidence)
NCBI Gene

76959

			Length	Strain/Species	Flank
genomic	76959	NCBI Gene Model \| MGI Sequence Detail	16750	C57BL/6J	± kb
transcript	NM_029814	RefSeq \| MGI Sequence Detail	1372	C57BL/6
polypeptide	Q9D7S9	UniProt \| EBI \| MGI Sequence Detail	219	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000005439 charged multivesicular body protein 5

(term hierarchy)
InterPro Domains

IPR005024 Snf7 family

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All nucleic 121

cDNA 120

Other 1

Microarray probesets 3

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MGI:2140590

Summaries

All 44

Developmental Gene Expression 2

Gene Ontology 13

Phenotypes 10
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Chmp5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr36826	Chr4:40948401-40948412 (+)	-146 bp
Tssr36827	Chr4:40948493-40948504 (+)	-54 bp
Tssr36828	Chr4:40948521-40948530 (+)	-27 bp
Tssr36829	Chr4:40948535-40948589 (+)	9 bp
Tssr36830	Chr4:40964852-40964869 (+)	16,308 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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