Dusp3 MGI Mouse Gene Detail - MGI:1919599 - dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)

Symbol

Dusp3
Name

dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)
Synonyms

2210015O03Rik, 5031436O03Rik, T-DSP11, VHR

Feature Type

protein coding gene
IDs

MGI:1919599
NCBI Gene: 72349
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr11:101861969-101877839 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 65.48 cM, cytoband D
Mapping Data

3 experiments

SNPs within 2kb

443 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919599	protein coding gene	Chr11:101861967-101877839 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019215	protein coding gene	Chr11:104912549-104928395 (-)
A/J	MGP_AJ_G0019183	protein coding gene	Chr11:100481818-100497991 (-)
AKR/J	MGP_AKRJ_G0019152	protein coding gene	Chr11:103594273-103612204 (-)
BALB/cJ	MGP_BALBcJ_G0019157	protein coding gene	Chr11:100966460-100982324 (-)
C3H/HeJ	MGP_C3HHeJ_G0018966	protein coding gene	Chr11:103799947-103815790 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019606	protein coding gene	Chr11:108184861-108200705 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017232	protein coding gene	Chr11:97905737-97922239 (-)
CAST/EiJ	MGP_CASTEiJ_G0018520	protein coding gene	Chr11:104764188-104780395 (-)
CBA/J	MGP_CBAJ_G0018935	protein coding gene	Chr11:112649523-112665367 (-)
DBA/2J	MGP_DBA2J_G0019047	protein coding gene	Chr11:100007375-100023566 (-)
FVB/NJ	MGP_FVBNJ_G0019037	protein coding gene	Chr11:99533851-99549763 (-)
LP/J	MGP_LPJ_G0019116	protein coding gene	Chr11:105429175-105445190 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019068	protein coding gene	Chr11:112178477-112194334 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019644	protein coding gene	Chr11:103956348-103972173 (-)
PWK/PhJ	MGP_PWKPhJ_G0018283	protein coding gene	Chr11:101067312-101083446 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018075	protein coding gene	Chr11:103698479-103719736 (-)
WSB/EiJ	MGP_WSBEiJ_G0018569	protein coding gene	Chr11:103941580-103957391 (-)

Human Ortholog

DUSP3, dual specificity phosphatase 3

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DUSP3, dual specificity phosphatase 3
Synonyms

VHR
Links

HGNC:3069

NCBI Gene ID: 1845

neXtProt AC: NX_P51452

UniProt: P51452
Chr Location

17q21.31; chr17:43766125-43778977 (-) GRCh38

MGI Vertebrate Homology

Dusp3 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: DUSP3
Gene Tree

Dusp3

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Phenotype Summary

10 phenotypes from 3 alleles in 3 genetic backgrounds
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

2
Targeted

6
Genomic Mutations

1 involving Dusp3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

24 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit decreased hemoglobin content and angiogenesis in Matrigel plugs and aortic explants.

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All GO Annotations

50
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

782
Tissues

47
cDNA Data

10
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dusp3

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All Sequences

60
RefSeq

8
UniProt

6
CCDS

CCDS25482.1

Ensembl

ENSMUSG00000003518 (Evidence)
NCBI Gene

72349

			Length	Strain/Species	Flank
genomic	ENSMUSG00000003518	Ensembl Gene Model \| MGI Sequence Detail	15871	C57BL/6J	± kb
transcript	ENSMUST00000107173	Ensembl \| MGI Sequence Detail	4311	Not Applicable
polypeptide	ENSMUSP00000102791	Ensembl \| MGI Sequence Detail	210	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000006753 dual specificity protein phosphatase 3

(term hierarchy)
PDB

8TO0
EC

3.1.3.16, 3.1.3.48
InterPro Domains

IPR020405 Atypical dual specificity phosphatase, subfamily A

IPR000340 Dual specificity phosphatase, catalytic domain

IPR020422 Dual specificity protein phosphatase domain

IPR016130 Protein-tyrosine phosphatase, active site

IPR029021 Protein-tyrosine phosphatase-like

IPR000387 Tyrosine-specific protein phosphatases domain

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All nucleic 12

cDNA 11

Primer pair 1

Microarray probesets 6

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MGI:1923216

Summaries

All 61

Developmental Gene Expression 6

Gene Ontology 11

Phenotypes 20
Earliest

J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Dusp3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr110984	Chr11:101877830-101877839 (-)	4 bp
Tssr110983	Chr11:101877789-101877800 (-)	44 bp
Tssr3679	Chr11:101877782-101877783 (-)	56 bp
Tssr110982	Chr11:101875575-101875624 (-)	2,239 bp
Tssr110981	Chr11:101875554-101875567 (-)	2,278 bp
Tssr110980	Chr11:101864785-101864835 (-)	13,029 bp
Tssr110979	Chr11:101863768-101863785 (-)	14,062 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24