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Ggct Gene Detail
Summary
  • Symbol
    Ggct
  • Name
    gamma-glutamyl cyclotransferase
  • Synonyms
    A030007L17Rik, Gctg, Ggc
  • Feature Type
    protein coding gene
  • IDs
    MGI:95700
    NCBI Gene: 110175
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:54962080-54969947 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 27.26 cM
  • Mapping Data
    35 experiments
Strain
Comparison
more
  • SNPs within 2kb
    288 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95700
 protein coding gene Chr6:54959565-54969947 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030767
 protein coding gene Chr6:54372108-54384735 (-)
A/J MGP_AJ_G0030736
 protein coding gene Chr6:51849025-51860511 (-)
AKR/J MGP_AKRJ_G0030663
 protein coding gene Chr6:53607603-53620805 (-)
BALB/cJ MGP_BALBcJ_G0030748
 protein coding gene Chr6:52212519-52223198 (-)
C3H/HeJ MGP_C3HHeJ_G0030461
 protein coding gene Chr6:53630399-53640768 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031203
 protein coding gene Chr6:55582901-55594632 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028409
 protein coding gene Chr6:49457390-49467361 (-)
CAST/EiJ MGP_CASTEiJ_G0029864
 protein coding gene Chr6:53494936-53505320 (-)
CBA/J MGP_CBAJ_G0030435
 protein coding gene Chr6:57884517-57896748 (-)
DBA/2J MGP_DBA2J_G0030585
 protein coding gene Chr6:51751256-51761769 (-)
FVB/NJ MGP_FVBNJ_G0030537
 protein coding gene Chr6:51344711-51354986 (-)
LP/J MGP_LPJ_G0030670
 protein coding gene Chr6:54313877-54324188 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030571
 protein coding gene Chr6:60395913-60406301 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031233
 protein coding gene Chr6:53576274-53588423 (-)
PWK/PhJ MGP_PWKPhJ_G0029577
 protein coding gene Chr6:51413419-51423792 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029411
 protein coding gene Chr6:52956402-52966595 (-)
WSB/EiJ MGP_WSBEiJ_G0029941
 protein coding gene Chr6:53601976-53612724 (-)



Homology
more
  • Human Ortholog
    GGCT, gamma-glutamylcyclotransferase
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GGCT, gamma-glutamylcyclotransferase
  • Synonyms
    C7orf24, CRF21, GCTG, GGC
  • Links
    NCBI Gene ID: 79017
    neXtProt AC: NX_O75223
    UniProt: O75223

  • Chr Location
    7p14.3; chr7:30496621-30504841 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit splenomegaly and progressive anemia associated with oxidative stress and reduced red blood cell life span.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    804
  • Tissues
    96
  • cDNA Data
    12
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 110175 NCBI Gene Model | MGI Sequence Detail 7868 C57BL/6J ±  kb
    transcript NM_026637 RefSeq | MGI Sequence Detail 1362 C57BL/6  
    polypeptide Q9D7X8 UniProt | EBI | MGI Sequence Detail 188 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 13

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-10058, MGI:1889375, MGI:1915502
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 2
      Gene Ontology 3
      Phenotypes 9
    • Earliest
      J:6673 Traina VL, et al., Genetic mapping of endogenous mouse mammary tumor viruses: locus characterization, segregation, and chromosomal distribution. J Virol. 1981 Dec;40(3):735-44
    • Latest
      J:340570 Bejarano E, et al., Unbalanced redox status network as an early pathological event in congenital cataracts. Redox Biol. 2023 Oct;66:102869
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory