Kcne2 MGI Mouse Gene Detail - MGI:1891123 - potassium voltage-gated channel, Isk-related subfamily, gene 2

Symbol

Kcne2
Name

potassium voltage-gated channel, Isk-related subfamily, gene 2
Synonyms

2200002I16Rik, MiRP1

Feature Type

protein coding gene
IDs

MGI:1891123
NCBI Gene: 246133
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr16:92089277-92095017 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 53.55 cM
Mapping Data

2 experiments

SNPs within 2kb

274 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1891123	protein coding gene	Chr16:92089277-92095021 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023053	protein coding gene	Chr16:93373720-93379460 (+)
A/J	MGP_AJ_G0023021	protein coding gene	Chr16:88995981-89001699 (+)
AKR/J	MGP_AKRJ_G0022991	protein coding gene	Chr16:91707591-91713577 (+)
BALB/cJ	MGP_BALBcJ_G0023023	protein coding gene	Chr16:89522893-89530219 (+)
C3H/HeJ	MGP_C3HHeJ_G0022784	protein coding gene	Chr16:92248241-92255022 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023470	protein coding gene	Chr16:96345814-96351554 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020972	protein coding gene	Chr16:86682961-86688259 (+)
CAST/EiJ	MGP_CASTEiJ_G0022303	protein coding gene	Chr16:92844396-92850096 (+)
CBA/J	MGP_CBAJ_G0022753	protein coding gene	Chr16:100489342-100496941 (+)
DBA/2J	MGP_DBA2J_G0022887	protein coding gene	Chr16:88898325-88904065 (+)
FVB/NJ	MGP_FVBNJ_G0022861	protein coding gene	Chr16:88025669-88031393 (+)
LP/J	MGP_LPJ_G0022957	protein coding gene	Chr16:93059160-93064900 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022882	protein coding gene	Chr16:104998524-105004316 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023488	protein coding gene	Chr16:92215675-92221415 (+)
PWK/PhJ	MGP_PWKPhJ_G0022048	protein coding gene	Chr16:89084913-89090817 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021878	protein coding gene	Chr16:91777808-91784939 (+)
WSB/EiJ	MGP_WSBEiJ_G0022355	protein coding gene	Chr16:92452565-92458305 (+)

Human Ortholog

KCNE2, potassium voltage-gated channel subfamily E regulatory subunit 2

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KCNE2, potassium voltage-gated channel subfamily E regulatory subunit 2
Synonyms

ATFB4, LQT5, LQT6, MIRP1
Links

HGNC:6242

NCBI Gene ID: 9992

neXtProt AC: NX_Q9Y6J6

UniProt: Q9Y6J6
Chr Location

21q22.11; chr21:34364006-34371381 (+) GRCh38

MGI Vertebrate Homology

Kcne2 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: KCNE2
Gene Tree

Kcne2

Diseases

4 with human KCNE2 associations

				Human Disease	Mouse Models
				atrial fibrillation IDs atrial fibrillation DOID:0060224 ICD9CM:427.31 MESH:D001281 NCI:C50466 UMLS_CUI:C0004238
				familial atrial fibrillation IDs familial atrial fibrillation DOID:0050650 OMIM:607554 OMIM:608583 OMIM:608988 OMIM:611493 OMIM:611494 OMIM:612201 OMIM:612240 OMIM:613055 OMIM:613980 OMIM:614022 OMIM:614049 OMIM:614050 OMIM:615377 OMIM:615378 OMIM:615770 OMIM:PS608583 ORDO:334
				long QT syndrome IDs long QT syndrome DOID:2843 DOID:4069 ICD10CM:I45.81 ICD9CM:426.82 MESH:D008133 NCI:C34786 OMIM:PS192500 ORDO:768 UMLS_CUI:C0023976
				long QT syndrome 6 IDs long QT syndrome 6 DOID:0110648 ICD10CM:I45.8 MESH:C566333 OMIM:613693

Click on a disease name to see all genes associated with that disease.

References

4 with disease annotations

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Phenotype Summary

31 phenotypes from 2 alleles in 4 genetic backgrounds
4 phenotypes from multigenic genotypes
3 images
91 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Endonuclease-mediated

2
Spontaneous

1
Targeted

14
Genomic Mutations

9 involving Kcne2
Find Mice (IMSR)

10 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele show enlarged stomachs, reduced parietal cell proton secretion, altered parietal cell morphology, achlorhydria, hypergastrinemia, gastric hyperplasia, and increased gastric pH. Males homozygous for a different knock-out allele develop iron-deficient anemia.

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All GO Annotations

73
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

944
Tissues

152
cDNA Data

9
Literature Summary

17

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

35
RefSeq

4
UniProt

2
CCDS

CCDS28333.1

Ensembl

ENSMUSG00000039672 (Evidence)
NCBI Gene

246133

			Length	Strain/Species	Flank
genomic	ENSMUSG00000039672	Ensembl Gene Model \| MGI Sequence Detail	5741	C57BL/6J	± kb
transcript	ENSMUST00000047383	Ensembl \| MGI Sequence Detail	1690	Not Applicable
polypeptide	ENSMUSP00000048849	Ensembl \| MGI Sequence Detail	123	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000009256 potassium voltage-gated channel subfamily E member 2

(term hierarchy)
InterPro Domains

IPR000369 Potassium channel, voltage-dependent, beta subunit, KCNE

IPR005425 Potassium channel, voltage-dependent, beta subunit, KCNE2
GlyGen

Q9D808 2 sites, 2 N-linked glycans (2 sites)

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All nucleic 14

cDNA 9

Primer pair 4

Other 1

Microarray probesets 3

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MGI:1916393, MGI:2146614

Summaries

All 135

Developmental Gene Expression 17

Diseases 4

Gene Ontology 8

Phenotypes 91
Earliest

J:42265 Huang TT, et al., Superoxide-mediated cytotoxicity in superoxide dismutase-deficient fetal fibroblasts. Arch Biochem Biophys. 1997 Aug 15;344(2):424-32
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Kcne2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr139467	Chr16:92087997-92088002 (+)	-1,277 bp
Tssr139468	Chr16:92089218-92089229 (+)	-53 bp
Tssr139469	Chr16:92089250-92089263 (+)	-20 bp
Tssr139470	Chr16:92089268-92089285 (+)	0 bp
Tssr139471	Chr16:92089286-92089299 (+)	16 bp
Tssr139472	Chr16:92089338-92089349 (+)	67 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24