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Ppa1 Gene Detail
Summary
  • Symbol
    Ppa1
  • Name
    pyrophosphatase (inorganic) 1
  • Synonyms
    2010317E03Rik, Pyp
  • Feature Type
    protein coding gene
  • IDs
    MGI:97831
    NCBI Gene: 67895
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:61484400-61509944 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 32.25 cM, cytoband B4
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    753 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97831
 protein coding gene Chr10:61484331-61509947 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017284
 protein coding gene Chr10:61009037-61035833 (+)
A/J MGP_AJ_G0017262
 protein coding gene Chr10:59176990-59202590 (+)
AKR/J MGP_AKRJ_G0017222
 protein coding gene Chr10:60722028-60747647 (+)
BALB/cJ MGP_BALBcJ_G0017222
 protein coding gene Chr10:59252686-59278350 (+)
C3H/HeJ MGP_C3HHeJ_G0017045
 protein coding gene Chr10:60623133-60650208 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017680
 protein coding gene Chr10:63191325-63218216 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015371
 protein coding gene Chr10:56150668-56179704 (+)
CAST/EiJ MGP_CASTEiJ_G0016616
 protein coding gene Chr10:60637638-60666296 (+)
CBA/J MGP_CBAJ_G0017017
 protein coding gene Chr10:65559048-65584642 (+)
DBA/2J MGP_DBA2J_G0017122
 protein coding gene Chr10:58448130-58473852 (+)
FVB/NJ MGP_FVBNJ_G0017116
 protein coding gene Chr10:57699671-57725540 (+)
LP/J MGP_LPJ_G0017197
 protein coding gene Chr10:61402454-61431540 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017144
 protein coding gene Chr10:67850987-67880357 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017718
 protein coding gene Chr10:60543544-60572024 (+)
PWK/PhJ MGP_PWKPhJ_G0016399
 protein coding gene Chr10:58293973-58320710 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016182
 protein coding gene Chr10:59896945-59927201 (+)
WSB/EiJ MGP_WSBEiJ_G0016680
 protein coding gene Chr10:60461014-60488441 (+)



Homology
more
  • Human Ortholog
    PPA1, inorganic pyrophosphatase 1
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPA1, inorganic pyrophosphatase 1
  • Synonyms
    HEL-S-66p, IOPPP, PP, PP1, SID6-8061
  • Links
    NCBI Gene ID: 5464
    neXtProt AC: NX_Q15181
    UniProt: Q15181

  • Chr Location
    10q22.1; chr10:70202835-70233911 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    968
  • Tissues
    115
  • cDNA Data
    169
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 67895 NCBI Gene Model | MGI Sequence Detail 25545 C57BL/6J ±  kb
transcript NM_026438 RefSeq | MGI Sequence Detail 1292 ZRU/MplStud  
polypeptide Q9D819 UniProt | EBI | MGI Sequence Detail 289 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 170
    cDNA 170

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-13704, MGI:1915145
References
more
  • Summaries
    All 52
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 16
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:340635 Sun Y, et al., Cold-inducible PPA1 is critical for the adipocyte browning in mice. Biochem Biophys Res Commun. 2023 Oct 15;677:45-53
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory