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Alkbh4 Gene Detail
Summary
  • Symbol
    Alkbh4
  • Name
    alkB homolog 4, lysine demethylase
  • Synonyms
    2010004B12Rik, Abj4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919291
    NCBI Gene: 72041
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:136165000-136170469 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 75.82 cM, cytoband G1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    126 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919291
 protein coding gene Chr5:136164999-136170654 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030202
 protein coding gene Chr5:140761290-140766759 (+)
A/J MGP_AJ_G0030170
 protein coding gene Chr5:134702571-134708040 (+)
AKR/J MGP_AKRJ_G0030103
 protein coding gene Chr5:139055584-139061053 (+)
BALB/cJ MGP_BALBcJ_G0030180
 protein coding gene Chr5:136059971-136065440 (+)
C3H/HeJ MGP_C3HHeJ_G0029896
 protein coding gene Chr5:139675938-139681407 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030633
 protein coding gene Chr5:145996719-146002188 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027853
 protein coding gene Chr5:128983342-128989106 (+)
CAST/EiJ MGP_CASTEiJ_G0029306
 protein coding gene Chr5:139076636-139082090 (+)
CBA/J MGP_CBAJ_G0029866
 protein coding gene Chr5:151701499-151706968 (+)
DBA/2J MGP_DBA2J_G0030017
 protein coding gene Chr5:134602788-134608257 (+)
FVB/NJ MGP_FVBNJ_G0029972
 protein coding gene Chr5:133757145-133762614 (+)
LP/J MGP_LPJ_G0030106
 protein coding gene Chr5:141188173-141193909 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030004
 protein coding gene Chr5:154674914-154680383 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030673
 protein coding gene Chr5:138873727-138879196 (+)
PWK/PhJ MGP_PWKPhJ_G0029019
 protein coding gene Chr5:133661774-133667356 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028855
 protein coding gene Chr5:136422941-136428410 (+)
WSB/EiJ MGP_WSBEiJ_G0029379
 protein coding gene Chr5:139595091-139600560 (+)



Homology
more
  • Human Ortholog
    ALKBH4, alkB homolog 4, lysine demethylase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ALKBH4, alkB homolog 4, lysine demethylase
  • Synonyms
    ABH4
  • Links
    NCBI Gene ID: 54784
    neXtProt AC: NX_Q9NXW9
    UniProt: Q9NXW9

  • Chr Location
    7q22.1; chr7:102456238-102464863 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted mutation exhibit lethality prior to weaning. Mice homozygous for a floxed allele activated in mouse embryonic fibroblasts exhibit decreased migration and impaired cytokinesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    14
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039754 Ensembl Gene Model | MGI Sequence Detail 5470 C57BL/6J ±  kb
transcript ENSMUST00000041100 Ensembl | MGI Sequence Detail 1773 Not Applicable  
polypeptide ENSMUSP00000040403 Ensembl | MGI Sequence Detail 300 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 16
    Genomic 2
    cDNA 14

    Microarray probesets 5
References
more
  • Summaries
    All 38
    Developmental Gene Expression 1
    Gene Ontology 10
    Phenotypes 7
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:278437 Kweon SM, et al., An Adversarial DNA N(6)-Methyladenine-Sensor Network Preserves Polycomb Silencing. Mol Cell. 2019 Jun 20;74(6):1138-1147.e6
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory